Skip to main content

Epigenetic State Modeling Utility

Project description

Epigenetic Pacemaker

A fast conditional expectation maximization algorithm for modeling epigenetic state

DNA methylation is widely used to model physiological phenotypes, such as aging1 and type II diabetes2. The epigenetic pacemaker, EPM, is an implementation of the a fast conditional expectation maximization algorithm for modeling epigenetic states associated with a phenotype of interest 3 The EPM was first introduced by Snir et al. 4 as an extension of the Universal Pacemaker (UPM) to model epigenetic aging. Additionally, the EPM can model non-linear epigenetic trait associations directly without transformation of the phenotype of interest5.


pip3 install EpigeneticPacemaker



  1. Horvath, S. DNA methylation age of human tissues and cell types. Genome Biol. 14, R115 (2013).
  2. Orozco, L. D. et al. Epigenome-wide association in adipose tissue from the METSIM cohort. Hum. Mol. Genet. 0, 223495 (2018).
  3. Snir, S. & Pellegrini, M. An epigenetic pacemaker is detected via a fast conditional expectation maximization algorithm. 10, 695–706 (2018).
  4. Snir, S., vonHoldt, B. M. & Pellegrini, M. A Statistical Framework to Identify Deviation from Time Linearity in Epigenetic Aging. PLoS Comput. Biol. 12, 1–15 (2016).
  5. Snir, S., Farrell, C. & Pellegrini, M. Human epigenetic ageing is logarithmic with time across the entire lifespan. Epigenetics (2019). doi:10.1080/15592294.2019.1623634

Project details

Download files

Download the file for your platform. If you're not sure which to choose, learn more about installing packages.

Files for EpigeneticPacemaker, version 0.0.2
Filename, size File type Python version Upload date Hashes
Filename, size EpigeneticPacemaker-0.0.2.tar.gz (42.3 MB) File type Source Python version None Upload date Hashes View

Supported by

AWS AWS Cloud computing Datadog Datadog Monitoring DigiCert DigiCert EV certificate Facebook / Instagram Facebook / Instagram PSF Sponsor Fastly Fastly CDN Google Google Object Storage and Download Analytics Pingdom Pingdom Monitoring Salesforce Salesforce PSF Sponsor Sentry Sentry Error logging StatusPage StatusPage Status page