Skip to main content
<p align="center">
<img src="https://github.com/WilsonSayresLab/XYalign/blob/master/Files/XYlogo.png" width="500"/>
</p>

# XYalign: Inferring Sex Chromosome Ploidy in NGS Data
Timothy H. Webster, Madeline Couse, Bruno Grande, Eric Karlins, Tanya Phung, Phillip Richmond, Whitney Whitford, Melissa A. Wilson Sayres

## Background
The high degree of similarity between gametologous sequences on the sex chromosomes can lead to the misalignment of sequencing reads and substantially affect variant calling. Here we present XYalign, a new tool that (1) quickly infers sex chromosome ploidy in NGS data, (2) remaps reads based on the inferred sex chromosome complement of the individual, and (3) outputs quality, depth, and allele-balance metrics across chromosomes.

[October 17, 2016 slide show of concept and inital results for Hackseq](https://docs.google.com/presentation/d/1OB2d_mu5zC742N_NKfzHjVpUm4BFtm5lUzniLLI--OQ/edit?usp=sharing)

[November 18, 2016 poster presentation for the Evolutionary Genomics of Sex 2016 Meeting](https://figshare.com/articles/XYalign_Inferring_and_Correcting_for_Sex_Chromosome_Ploidy_in_Next-Generation_Sequencing_Data/4292924/1)

## Using XYalign

See full documentation at [Read The Docs](http://xyalign.readthedocs.io/en/latest/index.html)

Post any questions you have at the [XYalign Google Group](https://groups.google.com/forum/#!forum/xyalign)

## If you cloned XYalign before April 5, 2017 please clone a fresh version
On April 5th, we removed a host of large files using BFG Repo Cleaner, which changed
the commit history of the repo. Because of this, ```git pull``` will no longer work on clones
prior to this cleaning. Therefore, if you cloned before this date (or can't remember when you
cloned), it's probably a good idea to clone a fresh version.

## Group Members
Name | email | github ID
--- | --- | ---
Tim Webster | timothy.h.webster@asu.edu | @thw17
Madeline Couse| mhcouse@gmail.com | @Madelinehazel
Bruno Grande | bgrande@sfu.ca | @brunogrande
Eric Karlins | karlinser@mail.nih.gov | @ekarlins
Tanya Phung | tnphung@ucla.edu | @tnphung
Phillip Richmond | phillip.a.richmond@gmail.com | @Phillip-a-Richmond
Whitney Whitford | whitney.whitford@auckland.ac.nz | @whitneywhitford
Melissa A. Wilson Sayres | melissa.wilsonsayres@asu.edu | @mwilsonsayres


Metadata

Release files for XYalign 1.1.3

For a detailed explanation of source distributions (sdists) and built distributions (wheels), please see the package formats documentation.

Source distribution (sdist)

Source distribution for XYalign 1.1.3
File Size Uploaded
XYalign-1.1.3.tar.gz 54.4 kB Details

Built distribution (wheel)

Table of built distributions (wheels) for XYalign 1.1.3
File Interpreter ABI Platform
XYalign-1.1.3-py2-none-any.whl Python 2 none any Details

Total release size: 126.9 kB

Release files / XYalign-1.1.3.tar.gz

Download URL XYalign-1.1.3.tar.gz
Size 54.4 kB
Tags Source
SHA-256 checksum
How to use checksums
c6f3d483bbb3d5ee2f60441a9ed3752146a735a1d806efdc0916417b487d37e6
BLAKE2b-256 checksum
How to use checksums
68362c92bbfb62d42192752f5457e85cdf8975809d2027db1e5f4928612660d2
Upload date
Uploaded using Trusted Publishing?
What is trusted publishing?
No

Release files / XYalign-1.1.3-py2-none-any.whl

Download URL XYalign-1.1.3-py2-none-any.whl
Size 72.5 kB
Tags Python 2
SHA-256 checksum
How to use checksums
ba0bc013639ab9c8f520c12fb01ffa0aa770b5ab9c37fe785e22ea2f57f3d9ba
BLAKE2b-256 checksum
How to use checksums
7f031a975c162c5d5b79289989a5c86f999950baba9cd2a3b1699dc4ed089664
Upload date
Uploaded using Trusted Publishing?
What is trusted publishing?
No

Release history Release notifications | RSS feed

1.1.5

2 release files

1.1.4

2 release files

This release

1.1.3 This release

2 release files

1.1.2

2 release files

1.1.1

2 release files

1.0.0

1 release file

Anthropic, PBC Visionary sponsor Bloomberg Visionary sponsor Hudson River Trading Visionary sponsor Meta Visionary sponsor NVIDIA Visionary sponsor Microsoft Sustainability sponsor Depot Continuous Integration AWS Cloud computing and Security Sponsor Datadog Monitoring Fastly CDN Google Download Analytics Sentry Error logging StatusPage Status page