Pantograph is a toolbox for the reconstruction, curation and validation of metabolic models.
Project description
Pantograph is a toolbox for the reconstruction, curation and validation of metabolic models. This is the unstable, development branch of Pantograph. For the stable 0.1 line and documentation, and for many of the scripts not included here, please check the website cited below.
Usage:
$ pantograph -x scaffold.xml -i inparanoid.data -m orthomcl.data -s org1 -t org2 -o out.xml -l out.log
Where scaffold.txt is an existing, well-curated SBML metabolic model, used as a template for the reconstruction; inparanoid.data is the output from Inparanoid, comparing the genes from the template and the reconstructed model; orthomcl.data is the output from OrthoMCL, where org1 is the template model and org2 is the reconstructed model; out.xml is the SBML reconstructed model and out.log is the reconstruction log. You can reconstruct a model using any of the two orthology methods (Inparanoid or OrthoMCL), although better results are obtained using both.
Pantograph has been tested under Linux and OS X, but not under Windows.
For more information, see our website: http://pathtastic.gforge.inria.fr
- If you use Pantograph for your own reconstructions, please cite:
Nicolas Loira, Anna Zhukova and David J Sherman. Pantograph: A template-based method for genome-scale metabolic model reconstruction. J Bioinform Comput Biol, 13(2): 1550006, 2015. DOI: 10.1142/S0219720015500067
For any question, please contact: Nicolas Loira nloira@gmail.com
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