compath-resources 0.0.3

ComPath Resource Utilities.

This repository contains the different resources derived or generated using ComPath. Among these resources, there are Jupyter notebooks outlining possible analyses that can be made using ComPath plugins as well as the results of the curation effort (‘mappings’ folder) where we generated pathway mappings between three of the major pathway databases (see below).

Citation

If you use ComPath in your work, please cite:

Domingo-Fernández, D., et al. (2018). ComPath: An ecosystem for exploring, analyzing, and curating mappings across pathway databases. bioRxiv 353235.

Curation (Pathway Mappings)

The aim of this exercise was to generate mapping files across pathway databases in order to establish relationships between similar pathways in three of the major pathway databases:

• KEGG

• Reactome

• WikiPathways

We recommend to download the mappings directly from the ComPath website since the pathways in WikiPathways are not stable and might have been changed. However, the mapping file distributed by the website contains stable identifiers from all resources.

Mapping Between Pathway Databases

A total of 3 mapping files are stored in this package, one for each pairwise comparison:

• KEGG - WikiPathways

• KEGG - Reactome

• WikiPathways - Reactome

It is important to mention that even more mappings are stored in the database thanks to the ComPath inference system. For example, when a KEGG to WikiPathways pathway is assigned as equivalent to a Reactome pathway, ComPath uses the Reactome hierarchy to infer new hierarchical mappings and map the super/sub pathways of the Reactome pathway to this corresponding equivalent pathway.

Curation Team

The curation exercise was conducted under inter-curator agreement in a team formed by:

• Carlos Bobis-Álvarez

• Josep Marín-Llaó

• Daniel Domingo-Fernández

Mapping Types

We have distinguished between two types of relationships between pathways (mappings): “equivalentTo” and “isPartOf”.

• equivalentTo. An undirected relationship denoting both pathways refer to the same biological process. The requirements for this relationship are:

  • Scope: both pathways represent the same biological pathway information.

  • Similarity: both pathways must share at minimum of one overlapping gene.

  • Context: both pathways should take place in the same context (e.g., cell line, physiology)

• isPartOf. A directed relationship denoting the hierarchical relationship between the pathway 1 (child) and 2 (parent). The requirements are:

  • Subset: The subject (pathway 1) is a subset of pathway 2 (e.g., Reactome pathway hierarchy).

  • Similarity: same as above

  • Context: same as above