Protein sequence diversity is one of the major challenges in the design of diagnostic, prophylactic and therapeutic
interventions against viruses. DiMA is a tool designed to facilitate the dissection of protein sequence diversity
dynamics for viruses. DiMA provides a quantitative measure of sequence diversity by use of Shannon’s entropy,
applied via a user-defined k-mer sliding window. Further, the entropy value is corrected for sample size bias by
applying a statistical adjustment.
Additionally, DiMA further interrogates the diversity by dissecting the entropy value at each k-mer position to various
diversity motifs. The distinct k-mer sequences at each position are classified into the following motifs based on
their incidence.
Moreover, the description line of the sequences in the alignment can be
formatted for inclusion of meta-data that can be tagged to the diversity motifs. DiMA enables comparative diversity
dynamics analysis, within and between proteins of a virus species, and proteomes of different viral species.
Click to view basic results
{
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},
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{
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{
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{
"sequence": "SKEIKSFLW",
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"incidence": 80.0,
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}
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{
"sequence": "KEIKSFLWT",
"count": 4,
"incidence": 80.0,
"motif_short": "I",
"motif_long": "Index",
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{
"sequence": "YMGNLSSQQ",
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{
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{
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{
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{
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{
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{
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{
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{
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"diversity_motifs": [
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{
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{
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]
}
Click to view advanced results
{
"sequence_count": 5,
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"query_name": "Unknown Query",
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"results": [
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"Year": {
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},
{
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