fastalite

The simplest possible fasta and fastq parsers I could come up with. Useful for simple manipulations of sequence files without creating complex dependencies.

The fastalite and fastqlite functions return an iterator of namedtuples, each with attributes id, (the header line before the first whitespace) description (the entire header line), and seq (the sequence as a string). fastqlite output also has an attribute qual containing the quality scores. For example:

from fastalite import fastalite

with open('inseqs.fasta') as infile, open('outseqs.fasta', 'w') as outfile:
    for seq in fastalite(infile):
        outfile.write('>{}\n{}\n'.format(seq.id, seq.seq))

The fastqlite parser also performs some limited error checking and raises ValueError when it encounters a malformed record.

The Opener class may be used in place of argparse.FileType to support transparent reading and writing of compressed files (inferred from a .gz or .bz2 suffix), for example:

import argparse
from fastalite import Opener, fastalite

parser = argparse.ArgumentParser()
parser.add_argument('infile', type=Opener())
args = parser.parse_args(arguments)
seqs = fastalite(args.infile)

You can perform a few actions on input files using the command line interface. For a list of available commands:

python -m fastalite -h

pip install fastalite

pip install git+https://github.com/nhoffman/fastalite.git

python setup.py test