Prerequisites

• natsort (3.5.2)

• nosetests, testfixtures (3.0.2), and numpy (>=1.7.1) are required for running automated tests

Installing

The easiest way to install Jacquard is through PyPI. Get pip if it’s not available in your system:

$ pip install jacquard

You can install from source from github:

$ pip install git+https://github.com/umich-brcf-bioinf/Jacquard

If you don’t have root permissions, you can install locally:

$ pip install --user jacquard

1.1.5 (10/26/2020)

• Adjusted Mutect translate to handle new style tumor/normal sample metaheaders.

• Adjusted Mutect translate to clarify supported versions of Mutect.

1.1.4 (9/29/2020)

• Adjusted summarize to ignore phasing when creating consensus GT.

• Adjusted Mutect handling to correctly marked phased normal (0|0) as non-somatic.

• Removed extraneous fields from JQ_VS_LOW_CONFIDENCE filter metaheader.

1.1.3 (9/24/2020)

• Adjusted Mutect handling to accommodate either older FA or newer AF allele frequency tags.

1.1.2 (7/11/2019)

• Adjusted VCF handling to correctly pad optional trailing FORMAT fields

• Adjusted Mutect translation to regard PASS as somatic when FilterMutectCalls present in metaheaders.

1.1.1 (10/30/2018)

• Adjusted Mutect translators to:

  • parse normal and tumor designations from SAMPLE metaheaders if available

  • recognize more variations of Mutect metaheader formats

1.1.0 (6/18/2018)

• Adjusted translate to correctly parse newer versions of Mutect

• Updated supported versions for Mutect, Strelka, Varscan

• Fixed error in JQ_SUMMARY_DP_AVERAGE tag description

1.0.0 (6/5/2018)

• Removed obsolete spikes directory

• Fixed bug in expand which could overwrite fixed VCF fields (e.g. REF, ALT, etc.) if identically named fields in INFO.

• Switched to semantic versioning

0.42 (9/22/2015)

• Added docs on readthedocs.

• Improved workflow documentation with example data

• Merge will now disambiguate tag collisions from multiple VCs

• Translate/summarize now supports GT tags

• Extended precision to 4 decimal places to support analysis of gene-panels.

• Adjusted translate to handle empty high-confidence VarScan files.

0.41 (5/7/2015)

• Combined filter command with merge command

• Extended expand to create simple metaheader glossary

• Adjusted code to support Python >=2.7 or 3.x

• Improved checks for consistent VCF file sets

• Fixed bug in merge that caused error if any VCFs were unsorted

• Fixed bug in summarize that caused error if variant was called by subset of callers

0.31 (3/17/2015)

• Downgraded VCF format from 4.2 to 4.1

• Fixed a bug that omitted CALLERS_REPORTED_LIST summary tag

• Simplified summary tags; removed dependency on numpy

• Adjusted VarScan translation to accept a file pattern to identify high-confidence files

0.3 (3/9/2015)

• Replaced normalize, tag commands with translate; relaxed constraints on incoming data.

• Renamed consensus to summarize

• More consistent behavior in expand

• Significantly improved merge performance

• Added new summary tags:

  • CALLERS_REPORTED_COUNT

  • CALLERS_REPORTED_LIST

  • SAMPLES_REPORTED_COUNT

  • CALLERS_PASSED_COUNT

  • CALLERS_PASSED_LIST

  • SAMPLES_PASSED_COUNT

• Fixed bug in how Strelka calculated AF on indels

• Improved command validation and error handling

• Added project/code documentation

• Removed dependencies on pandas

0.21 (10/2014)

• Initial public release

Jacquard is written and maintained by the University of Michigan BRCF Bioinformatic Core; individual contributors include:

• Jessica Bene

• Ashwini Bhasi

• Chris Gates

• Divya Kriti

• Kevin Meng

• Peter Ulintz