madic 0.1.0

MAtrix-Dependent Interference Correction of targeted mass spectrometry data

Overview

madic is a Python package for detecting and correcting interference in targeted mass spectrometry data using high-performance Pandas data structures.

Purpose

Multiple reaction monitoring (MRM, also known as selected reaction monitoring / SRM) data acquired during targeted mass spectrometry experiments can suffer from complex interference patterns that hinder accurate quantification. This software identifies and corrects interference, as well increases the confidence of peptide calls according to three qualities of an ideal chromatogram: relative transition ratios similar to synthetic standards, co-elution of all individual target transitions with respective stable isotope labeled (SIL) transitions, and a distinguished peak relative to the background. Additionally, these criteria should be satisfied for all replicate injections of a given sample.

More information

Follow the github URL below for more information.