A Modular Single-Molecule Analysis Interface.
Project description
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MOSAIC: A modular single-molecule analysis interface
=================================
MOSAIC is a single molecule analysis toolbox that automatically decodes multi-state nanopore data. By modeling the nanopore system with an equivalent circuit, MOSAIC leverages the transient response of a molecule entering the channel to quantify pore-molecule interactions. In contrast to existing techniques such as ionic current thresholding or Viterbi decoding, this technique allows the estimation of short-lived transient events that are otherwise not analyzed.
Nanometer-scale pores have demonstrated potential use in biotechnology applications, including DNA sequencing, single-molecule force spectroscopy, and single-molecule mass spectrometry. The data modeling and analysis methods implemented in MOSAIC allow for dramatic improvements in the quantification of molecular interactions with the channel in each of these applications.
**If you use MOSAIC in your work, please cite both papers below:**
1. `Analytical Chemistry 2016, (88) pp. 11900–11907 <http://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b03725>`_
2. `ACS Nano 2014, (8) pp. 1547–1553. <http://pubs.acs.org/doi/abs/10.1021/nn405761y>`_
Installation
=================================
Please refer to the `Installation <https://pages.nist.gov/mosaic/html/doc/GettingStarted.html>`_ section of the MOSAIC documentation for details on installation.
Getting Help
=================================
If you need help or have questions, please join our mailing list.
To subscribe:
Visit `https://groups.google.com/a/list.nist.gov/group/mosaic/ <https://groups.google.com/a/list.nist.gov/group/mosaic/>`_.
To unsubscribe:
Email `mosaic+unsubscribe@list.nist.gov <mailto:mosaic+unsubscribe@list.nist.gov>`_.
Once subscribed, you can send messages by emailing `mosaic@list.nist.gov <mailto:mosaic@list.nist.gov>`_.
Reporting Problems
=================================
Report problems using our `issue tracker <https://github.com/usnistgov/mosaic/issues>`_ on Github.
What's New?
=================================
Read the `Change Log <CHANGELOG.rst>`_
:target: https://travis-ci.org/usnistgov/mosaic
.. image:: https://badge.fury.io/gh/usnistgov%2Fmosaic.svg
:target: https://badge.fury.io/gh/usnistgov%2Fmosaic
MOSAIC: A modular single-molecule analysis interface
=================================
MOSAIC is a single molecule analysis toolbox that automatically decodes multi-state nanopore data. By modeling the nanopore system with an equivalent circuit, MOSAIC leverages the transient response of a molecule entering the channel to quantify pore-molecule interactions. In contrast to existing techniques such as ionic current thresholding or Viterbi decoding, this technique allows the estimation of short-lived transient events that are otherwise not analyzed.
Nanometer-scale pores have demonstrated potential use in biotechnology applications, including DNA sequencing, single-molecule force spectroscopy, and single-molecule mass spectrometry. The data modeling and analysis methods implemented in MOSAIC allow for dramatic improvements in the quantification of molecular interactions with the channel in each of these applications.
**If you use MOSAIC in your work, please cite both papers below:**
1. `Analytical Chemistry 2016, (88) pp. 11900–11907 <http://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b03725>`_
2. `ACS Nano 2014, (8) pp. 1547–1553. <http://pubs.acs.org/doi/abs/10.1021/nn405761y>`_
Installation
=================================
Please refer to the `Installation <https://pages.nist.gov/mosaic/html/doc/GettingStarted.html>`_ section of the MOSAIC documentation for details on installation.
Getting Help
=================================
If you need help or have questions, please join our mailing list.
To subscribe:
Visit `https://groups.google.com/a/list.nist.gov/group/mosaic/ <https://groups.google.com/a/list.nist.gov/group/mosaic/>`_.
To unsubscribe:
Email `mosaic+unsubscribe@list.nist.gov <mailto:mosaic+unsubscribe@list.nist.gov>`_.
Once subscribed, you can send messages by emailing `mosaic@list.nist.gov <mailto:mosaic@list.nist.gov>`_.
Reporting Problems
=================================
Report problems using our `issue tracker <https://github.com/usnistgov/mosaic/issues>`_ on Github.
What's New?
=================================
Read the `Change Log <CHANGELOG.rst>`_
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