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OncodriveFM

Project description

OncodriveFM detects candidate cancer driver genes and pathways from catalogs of somatic mutations in a cohort of tumors by computing the bias towards the accumulation of functional mutations (FM bias). This novel approach avoids some known limitations of recurrence-based approaches, such as the difficulty to estimate background mutation rate, and the fact that they usually fail to identify lowly recurrently mutated driver genes.

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