Skip to main content

An application to quantify and annotate miRNA expression.

Project description

microRNAs (miRNAs) are an important class of small noncoding RNAs (~22nt) with multiple and widespread regulatory roles in many development and disease processes. We have created the tool Prost! to explore metazoan miRNA-enriched RNA-Seq data. Prost! quantifies and normalizes expression levels (in the form of Illumina reads) in several views that are suitable as input into differential expression software such as DESeq2. Some key features of Prost! include the identification of both candidate mirror-miRNAs and putative 5 ́/3 ́ mature miRNA arm switching. Of particular interest is the tightly regulated post-transcriptional modification of miRNAs via multiple modes of regulation during their biogenesis. Such modifications have been found to have important consequences on characteristics such as Argonaute loading, target choice, and miRNA turnover. Prost! provides valuable quantification across samples of several classes of miRNA modifications, for example putative seed shifting, seed editing, and untemplated 3 ́ nucleotide additions.

Project details


Download files

Download the file for your platform. If you're not sure which to choose, learn more about installing packages.

Source Distribution

prost-0.7.23.tar.gz (69.5 kB view details)

Uploaded Source

File details

Details for the file prost-0.7.23.tar.gz.

File metadata

  • Download URL: prost-0.7.23.tar.gz
  • Upload date:
  • Size: 69.5 kB
  • Tags: Source
  • Uploaded using Trusted Publishing? No

File hashes

Hashes for prost-0.7.23.tar.gz
Algorithm Hash digest
SHA256 e8a8931819203821e099655fd24697d099bba235e6de76903a38891ee7d64bfa
MD5 da833263076918240a75647d7605edd1
BLAKE2b-256 3a7788dd43b000e5d5003011f06781e29accae1edd794969369a2eb3c151e4e9

See more details on using hashes here.

Supported by

AWS AWS Cloud computing and Security Sponsor Datadog Datadog Monitoring Fastly Fastly CDN Google Google Download Analytics Microsoft Microsoft PSF Sponsor Pingdom Pingdom Monitoring Sentry Sentry Error logging StatusPage StatusPage Status page