Python scripting library for generating designs readable by scadnano.
The scadnano Python module is a library for describing synthetic DNA nanostructures (e.g., DNA origami).
This module is used to write Python scripts outputting .dna files readable by [scadnano](https://web.cs.ucdavis.edu/~doty/scadnano/), a web application useful for displaying and manually editing these structures. The purpose of this module is to help automate some of the task of creating DNA designs, as well as making large-scale changes to them that are easier to describe programmatically than to do by hand in scadnano.
The scadnano Python package requires Python version 3.7 or later. If you do not have that version (or later) of Python installed, follow [this link](https://www.python.org/downloads/) to install it.
Once Python is installed, there are two ways you can install the scadnano Python package:
Use [pip](https://pypi.org/project/pip/) to install the package by executing the following at the command line: `console pip install scadnano `
If your Python installation does not already have pip installed, you may have to install it. Executing [this Python script](https://bootstrap.pypa.io/get-pip.py) should work; see also https://docs.python.org/3/installing/index.html or https://www.liquidweb.com/kb/install-pip-windows/.
As a simple alternative, you can download and place the following file(s) (located in the [scadnano/](https://github.com/UC-Davis-molecular-computing/scadnano-python-package/tree/master/scadnano) subfolder) in your PYTHONPATH (e.g., in the same directory as the scripts you are running):
- required: [scadnano.py](https://raw.githubusercontent.com/UC-Davis-molecular-computing/scadnano-python-package/master/scadnano/scadnano.py)
- optional: [origami_rectangle.py](https://raw.githubusercontent.com/UC-Davis-molecular-computing/scadnano-python-package/master/scadnano/origami_rectangle.py); This can help create origami rectangles, but it is not necessary to use scadnano.
Unfortunately, the scadnano package depends on the Python [xlwt](https://pypi.org/project/xlwt/), so xlwt must be installed. To install, type pip install xlwt at the command line. If this does not work, then you can comment out the line import xlwt in scadnano.py, but then you will not be able to call the method [DNADesign.write_idt_plate_excel_file()](https://web.cs.ucdavis.edu/~doty/scadnano/docs/#scadnano.scadnano.DNADesign.write_idt_plate_excel_file) to export an Excel file with DNA sequences.
Online documentation of the package API is located here: https://web.cs.ucdavis.edu/~doty/scadnano/docs/
A [tutorial](tutorial/tutorial.md) is available.
Several example scripts are located in the [examples/](https://github.com/UC-Davis-molecular-computing/scadnano-python-package/tree/master/examples) subfolder. Their output is contained in the [examples/output_designs/](https://github.com/UC-Davis-molecular-computing/scadnano-python-package/tree/master/examples/output_designs) subfolder.
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