Spatial Interaction Modeling using Variational Inference
Project description
SIMVI
SIMVI (Spatial Interaction Modelling using Variational Inference) is a deep generative framework for disentangling intrinsic variation and spatially-induced variation in spatial omics data. SIMVI has rigorous identifiability guarantee, and enables novel downstream analyses, including clustering and differential expression analysis based on disentangled representations, spatial effect identification, spatial effect attribution, and transfer learning on new measurements / modalities. SIMVI is implemented with scvi-tools.
Read our updated preprint on BioRxiv:
System requirements
OS requirements
The SIMVI package is supported for all OS in principle. The package has been tested on the following systems:
- macOS: Monterey (12.4)
- Linux: Ubantu (20.04.5)
Dependencies
See setup.cfg for details.
Installation
SIMVI requires python version 3.7+. Install directly from pip with:
pip install simvi
The installation should take no more than a few minutes on a normal desktop computer.
Usage
For detailed usage, follow our step-by-step tutorial here:
Download the dataset used for the tutorial here:
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