smallerize
A Python implementation of minimisation for clinical trials
Open source: Mozilla Public License 2.0
Documentation: https://smallerize.readthedocs.io.
Features
Implements minimization as described in Pocock + Simon (1975): Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial
Tested using pytest to ensure the results match the original implementation.
Pure Python module with no dependencies (pandas is useful when conducting simulations but is optional)
Includes all functions described in the article: range, standard deviation, variance, etc.
Also implements the biased-coin minimization method described in Han et al. (2009): Randomization by minimization for unbalanced treatment allocation, to allow for unequal allocation ratios.
Allows pure random assignment for comparison
Simulation module to allow simulating the effects of different assignment schemes.
Example
Comparing minimization to purely random assignment by simulation:
See the example notebook for details of the simulation.
Credits
This package was created with Cookiecutter and the audreyr/cookiecutter-pypackage project template.
History
0.5.0 (2019-05-08)
Improved performance with large numbers of factors/factor levels by making the count table sparse.
0.4.0 (2019-02-02)
Switched to Mozilla Public License.
0.3.0 (2019-01-02)
Make it easier to check the valid total imbalance and probability methods.
0.2.0 (2018-10-22)
Add the biased coin minimization method to allow for unequal treatment allocations.
0.1.0 (2018-10-07)
First release on PyPI.
Release files for smallerize 0.5.0
For a detailed explanation of source distributions (sdists) and built distributions (wheels), please see the package formats documentation.
Source distribution (sdist)
| File | Size | Uploaded | |
|---|---|---|---|
| smallerize-0.5.0.tar.gz | 31.7 kB | Details |
Built distribution (wheel)
| File | Interpreter | ABI | Platform | Reset |
|---|---|---|---|---|
| smallerize-0.5.0-py2.py3-none-any.whl | Python 3, Python 2 | none | any | Details |
Total release size: 48.2 kB
Release files / smallerize-0.5.0.tar.gz
| Download URL | smallerize-0.5.0.tar.gz |
|---|---|
| Size | 31.7 kB |
| Tags | Source |
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Release files / smallerize-0.5.0-py2.py3-none-any.whl
| Download URL | smallerize-0.5.0-py2.py3-none-any.whl |
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| Size | 16.5 kB |
| Tags | Python 2 Python 3 |
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