Skip to main content

Find splicing-led, functional changes of the proteome.

Project description

.. -*- mode: rst -*-

|Travis|_ |Codecov|_ |PyPi|_

.. |Travis| image:: https://api.travis-ci.org/hclimente/spada.svg?branch=master
.. _Travis: https://api.travis-ci.org/hclimente/spada

.. |Codecov| image:: https://codecov.io/github/hclimente/spada/badge.svg?branch=master&service=github
.. _Codecov: https://codecov.io/github/hclimente/spada?branch=master

.. |PyPi| image:: https://badge.fury.io/py/spada.svg
.. _PyPi: https://badge.fury.io/py/spada

SPADA
============

SPADA (Splicing-led Protein Alterations Discovered Agilely) is a tool to study the functional impact of alternative splicing changes between two conditions. The alterations have to be represented as isoform switches i.e. when one condition is best represented by one isoform, and the second condition by another one. Then, SPADA is able to predict which protein features are changing between both isoforms, and their impact on the protein-protein interaction network.

To start using SPADA, simply install it with ::

pip install spada

Documentation
----------------
Citation
~~~~~~~~~~~

If you use spada in a scientific publication, we would appreciate citations:

Climente-González, H., Porta-Pardo, E., Godzik, A., and Eyras, E. (2017). `The Functional Impact of Alternative Splicing in Cancer.`__ Cell Rep. 20, 2215–2226.

.. __: http://www.cell.com/cell-reports/abstract/S2211-1247(17)31104-X

Related projects
~~~~~~~~~~~
* smartas_ Analysis of `spada` applied results applied to TCGA data.

.. _smartas: https://github.com/hclimente/smartas


Project details


Download files

Download the file for your platform. If you're not sure which to choose, learn more about installing packages.

Filename, size & hash SHA256 hash help File type Python version Upload date
spada-1.21.10-py3-none-any.whl (67.9 kB) Copy SHA256 hash SHA256 Wheel py3

Supported by

Elastic Elastic Search Pingdom Pingdom Monitoring Google Google BigQuery Sentry Sentry Error logging AWS AWS Cloud computing DataDog DataDog Monitoring Fastly Fastly CDN SignalFx SignalFx Supporter DigiCert DigiCert EV certificate StatusPage StatusPage Status page