A tool for mapping free-text descriptions of (biomedical) entities to controlled terms in ontologies
Project description
text2term ontology mapper
A tool for mapping free-text descriptions of (biomedical) entities to controlled terms in ontologies.
Installation
Install package using pip:
pip install text2term
Examples
Programmatic
import text2term
import pandas
df1 = text2term.map_file("test/unstruct_terms.txt", "http://www.ebi.ac.uk/efo/efo.owl")
df2 = text2term.map_terms(["asthma", "acute bronchitis"], "http://www.ebi.ac.uk/efo/efo.owl")
Below is an example of caching, assuming the same imports as above:
text2term.cache_ontology("http://www.ebi.ac.uk/efo/efo.owl", "EFO")
df1 = text2term.map_file("test/unstruct_terms.txt", "EFO", use_cache=True)
df2 = text2term.map_terms(["asthma", "acute bronchitis"], "EFO", use_cache=True)
text2term.clear_cache("EFO")
Command Line
The basic use of the tool requires a source
file containing a list of terms to map to the given target
ontology:
python text2term -s test/unstruct_terms.txt -t http://www.ebi.ac.uk/efo/efo.owl
Specify an output file where the mappings should be saved using -o
:
python text2term -s test/unstruct_terms.txt -t efo.owl -o /Documents/my-mappings.csv
Set the minimum acceptable similarity score for mapping each given term to an ontology term using -min
:
python text2term -s test/unstruct_terms.txt -t efo.owl -min 0.8
The mapped terms returned will have been determined to be 0.8 similar to their source terms in a 0-1 scale.
Exclude deprecated ontology terms (declared as such via owl:deprecated true) using -d
:
python text2term -s test/unstruct_terms.txt -t efo.owl -d
Limit search to only terms whose IRIs start with any IRI given in a list specified using -iris
:
python text2term.py -s test/unstruct_terms.txt -t efo.owl -iris http://www.ebi.ac.uk/efo/EFO,http://purl.obolibrary.org/obo/HP
Here, because EFO reuses terms from other ontologies such as HP and GO, the HP terms would be included but the GO terms would be excluded.
Use the cache on the command line, first by flagging it, then in the future using the acronym:
python text2term -s test/unstruct_terms.txt -t http://www.ebi.ac.uk/efo/efo.owl -c EFO
Then, after running this, the following command is equivalent:
python text2term -s test/unstruct_terms.txt -t EFO
Programmatic Usage
The tool can be executed in Python with any of the three following functions:
text2term.map_file(input_file='/some/file.txt',
target_ontology='http://some.ontology/v1.owl',
base_iris=(),
csv_columns=(),
excl_deprecated=False,
max_mappings=3,
mapper=Mapper.TFIDF,
min_score=0.3,
output_file='',
save_graphs=False,
save_mappings=False,
separator=',',
use_cache=False,
term_type='classes')
or
text2term.map_terms(source_terms=['term one', 'term two'],
target_ontology='http://some.ontology/v1.owl',
base_iris=(),
excl_deprecated=False,
max_mappings=3,
min_score=0.3,
mapper=Mapper.TFIDF,
output_file='',
save_graphs=False,
save_mappings=False,
source_terms_ids=(),
use_cache=False,
term_type='classes')
or
text2term.map_tagged_terms(tagged_terms_dict={'term one': ["tag 1", "tag 2"]},
target_ontology='http://some.ontology/v1.owl',
base_iris=(),
excl_deprecated=False,
max_mappings=3,
min_score=0.3,
mapper=Mapper.TFIDF,
output_file='',
save_graphs=False,
save_mappings=False,
source_terms_ids=(),
use_cache=False,
term_type='classes')
Arguments
For map_file
, the first argument 'input_file' specifies a path to a file containing the terms to be mapped. It also has a csv_column
argument that allows the user to specify a column to map if a csv is passed in as the input file.
For map_terms
, the first argument 'source_terms' takes in a list of the terms to be mapped.
For map_tagged_terms
, everything is the same as map_terms
except the first argument is either a dictionary of terms to a list of tags, or a list of TaggedTerm objects (see below). Currently, the tags do not affect the mapping in any way, but they are added to the output dataframe at the end of the process.
All other arguments are the same, and have the same functionality:
target_ontology
: str
Path or URL of 'target' ontology to map the source terms to. When the chosen mapper is BioPortal or Zooma,
provide a comma-separated list of ontology acronyms (eg 'EFO,HPO') or write 'all' to search all ontologies
base_iris
: tuple
Map only to ontology terms whose IRIs start with one of the strings given in this tuple, for example:
('http://www.ebi.ac.uk/efo','http://purl.obolibrary.org/obo/HP')
source_terms_ids
: tuple
Collection of identifiers for the given source terms
WARNING: While this is still available for the tagged term function, it is worth noting that dictionaries do not necessarily preserve order, so it is not recommended. If using the TaggedTerm object, the source terms can be attached there to guarantee order.
excl_deprecated
: bool
Exclude ontology terms stated as deprecated via owl:deprecated true
mapper
: mapper.Mapper
Method used to compare source terms with ontology terms. One of: levenshtein, jaro, jarowinkler, jaccard, fuzzy, tfidf, zooma, bioportal
These can be initialized by invoking mapper.Mapper e.g. mapper.Mapper.TFIDF
max_mappings
: int
Maximum number of top-ranked mappings returned per source term
min_score
: float
Minimum similarity score [0,1] for the mappings (1=exact match)
output_file
: str
Path to desired output file for the mappings
save_graphs
: bool
Save vis.js graphs representing the neighborhood of each ontology term
save_mappings
: bool
Save the generated mappings to a file (specified by output_file
)
use_cache
: bool
Use the cache for the ontology. More details are below.
term_type
: str
Determines whether the ontology should be parsed for its classes (ThingClass), properties (PropertyClass), or both. Possible values are ['classes', 'properties', 'both']. If it does not match one of these values, the program will throw a ValueError.
All default values, if they exist, can be seen above.
Return Value
Both functions return the same value:
df
: Data frame containing the generated ontology mappings
Ontology Caching
As of version 1.1.0, users can cache ontologies that they want to use regularly or quickly. Programmatically, there are two steps to using the cache: creating the cache, then accessing it. First, the user can cache ontologies using either of two functions:
cache_ontology(ontology_url, ontology_acronym, base_iris=())
cache_ontology_set(ontology_registry_path)
The first of these will cache a single ontology from a URL or file path, with it being referenced by an acronym that will be used to reference it later. An example can be found above.
The second function allows the user to cache several ontologies at once by referencing a CSV file of the format:
acronym,version,url
. An example is provided in resources/ontologies.csv
Once an ontology has been cached by either function, it is stored in a cache folder locally, and thus can be referenced even in different Python instances.
NOTE: Due to how ontologies are processed in memory, cache_ontology_set
must be used to cache multiple ontologies in a single Python instance. If cache_ontology
is used multiple times in one instance, the behavior is undefined and may cause visible or invisible errors.
After an ontology is cached, the user can access the cache by using the assigned acronym in the place of target_ontology
and setting the use_cache
flag to True
.
To clear the cache, one can call:
clear_cache(ontology_acronym='')
If no arguments are specified, the entire cache will be cleared. Otherwise, only the ontology with the given acronym will be cleared.
Finally, cache_exists(ontology_acronym='')
is a simple function that returns True
if the given acronym exists in the cache, and False
otherwise. It is worth noting that while ontology URLs can repeat, acronyms must be distinct in a given environment.
Input Preprocessing
As of version 1.2.0, text2term includes regex-based preprocessing functionality for input terms. Specifically, these functions take the input terms and a collection of (user-defined) regular expressions, then match each term to each regular expression to simplify the input term.
Like the "map" functions above, the two functions differ on whether the input is a file or a list of strings:
preprocess_file(file_path, template_path, output_file='', blocklist_path='', blocklist_char='', rem_duplicates=False)
preprocess_terms(terms, template_path, output_file='', blocklist_path='', blocklist_char='', rem_duplicates=False)
preprocess_tagged_terms(file_path, template_path='', blocklist_path='', blocklist_char='', rem_duplicates=False, separator=';:;')
In all cases, the regex templates and blocklist must be stored in a newline-separated file. If an output file is specified, the preprocessed strings are written to that file and the list of preprocessed strings is returned.
The blocklist functionality allows the user to specify another regex file. If any terms match any regex in blocklist, they are removed from the terms, or, if a blocklist character is specified, replaced with that character for placeholding. NOTE: As of version 2.1.0, the arguments were changed to "blocklist" from "blacklist". Backwards compatibility is currently supported, but will likely be discontinued at the next major release.
The Remove Duplicates rem_duplicates
functionality will remove all duplicate terms after processing, if set to True
.
WARNING: Removing duplicates at any point does not guarantee which original term is kept. This is particularly important if original terms have different tags, so user caution is advised.
The functions preprocess_file()
and preprocess_terms()
both return a dictionary where the keys are the original terms and the values are the preprocessed terms.
The preprocess_tagged_terms()
function returns a list of TaggedTerm items with the following function contracts:
def __init__(self, term=None, tags=[], original_term=None, source_term_id=None)
def add_tags(self, new_tags)
def update_term(self, term)
def update_source_term_id(self, source_term_id)
def get_original_term(self)
def get_term(self)
def get_tags(self)
def get_source_term_id(self)
As mentioned in the mapping section above, this can then be passed directly to map_tagged_terms(), allowing for easy programmatic usage. Note that this allows multiple of the same preprocessed term with different tags.
Note on NA values in input: As of v2.0.3, when the input to text2term is a table file, any rows that contain NA
values in the specified term column, or in the term ID column (if provided), will be ignored.
Command Line Usage
After installation, execute the tool from a command line as follows:
python text2term -s SOURCE -t TARGET [-o OUTPUT] [-m MAPPER] [-csv CSV_INPUT] [-top TOP_MAPPINGS] [-min MIN_SCORE] [-iris BASE_IRIS] [-d EXCL_DEPRECATED] [-g SAVE_TERM_GRAPHS]
To display a help message with descriptions of tool arguments do:
python text2term -h
or python text2term --help
Required arguments
-s SOURCE
Input file containing 'source' terms to map to ontology terms (list of terms or CSV file).
-t TARGET
Path or URL of 'target' ontology to map source terms to. When the chosen mapper is BioPortal or Zooma, provide a comma-separated list of acronyms (eg 'EFO,HPO') or write 'all'
to search all ontologies.
Optional arguments
-o OUTPUT
Path to desired output file for the mappings.
-m MAPPER
Method used to compare source terms with ontology terms. One of: levenshtein, jaro, jarowinkler, jaccard, indel, fuzzy, tfidf, zooma, bioportal.
-csv CSV_INPUT
Indicates a CSV format input—follow with the name of the column containing terms to map, optionally followed by the name of the column containing identifiers for the terms (eg 'my terms,my term ids').
-top TOP_MAPPINGS
Maximum number of top-ranked mappings returned per source term.
-min MIN_SCORE
Minimum similarity score [0,1] for the mappings (1=exact match).
-iris BASE_IRIS
Map only to ontology terms whose IRIs start with a value given in this comma-separated list (eg 'http://www.ebi.ac.uk/efo,http://purl.obolibrary.org/obo/HP)').
-d EXCL_DEPRECATED
Exclude ontology terms stated as deprecated via owl:deprecated true
.
-g SAVE_TERM_GRAPHS
Save vis.js graphs representing the neighborhood of each ontology term.
-c STORE_IN_CACHE
Using this flag followed by the acronym the ontology should be stored as, the program will same the target ontology to the cache. After that, referencing the acronym in target
will reference the cache. Examples are above.
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