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# TopACeDo #### Topology Assisted Cell Downsampling

Topacedo works with Scarf to perform memory efficient downsampling of single-cell genomics data. Using a pre-built neighbourhood graph of cells, Topacedo aims to sample cells from the graph such that the manifold is preserved. Topecedo’s algorithm can be diveded into two phases:

  • assigning prizes to cells and penalties to edges

  • running a fast approximate prize-collecting steiner tree

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