As a Python Module

Wake up a single computer by its mac address

import wakeonlan

wakeonlan.wake('ff.ff.ff.ff.ff.ff')

Wake up a single computer by its mac address with a SecureOn password

import wakeonlan

wakeonlan.wake('ff.ff.ff.ff.ff.ff/01:23:45:67:89:ab')

Wake up multiple computers by their mac addresses.

import wakeonlan

wakeonlan.wake(
    'ff.ff.ff.ff.ff.ff',
    '00-00-00-00-00-00',
    'FFFFFFFFFFFF'
)

An external host may be specified. Do note that port forwarding on that host is required. The default ip address is 255.255.255.255 and the default port is 9.

import wakeonlan

wakeonlan.wake('ff.ff.ff.ff.ff.ff',
    host='example.com',
    port=1337
)

A network adapter may be specified. The magic packet will be routed through this interface.

import wakeonlan

wakeonlan.wake(
    'ff.ff.ff.ff.ff.ff',
    interface='192.168.0.2'
)

As a Standalone Script

$ wakeonlan --help
usage: wakeonlan [-h] [-4] [-6] [-o HOST] [-p PORT] [-n INTERFACE] mac address [mac address ...]

Wake one or more computers using the wake on lan protocol.

positional arguments:
mac address           The mac addresses or "mac address/secureon password" tuples of the computers you are trying to wake.

options:
-h, --help            show this help message and exit
-o HOST, --host HOST  The host name to send the magic packet to. (default: 255.255.255.255)
-p PORT, --port PORT  The port of the host to send the magic packet to. (default: 9)
-n INTERFACE, --interface INTERFACE
                      The ip address of the network adapter to route the magic packet through. (default: None)
-4, --ipv4            To indicate ipv4 should be used. (default: False)
-6, --ipv6            To indicate ipv6 should be used. (default: False)