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3D shape analysis using deep learning

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README

Project Status: Active – The project has reached a stable, usable state and is being actively developed.

Cellshape logo by Matt De Vries

3D single-cell shape analysis of cancer cells using geometric deep learning

This is a package for automatically learning and clustering cell shapes from 3D images. Please refer to our preprint on bioRxiv here

cellshape is available for everyone.

Graph neural network

https://github.com/Sentinal4D/cellshape-cloud Cellshape-cloud is an easy-to-use tool to analyse the shapes of cells using deep learning and, in particular, graph-neural networks. The tool provides the ability to train popular graph-based autoencoders on point cloud data of 2D and 3D single cell masks as well as providing pre-trained networks for inference.

Clustering

https://github.com/Sentinal4D/cellshape-cluster

Cellshape-cluster is an easy-to-use tool to analyse the cluster cells by their shape using deep learning and, in particular, deep-embedded-clustering. The tool provides the ability to train popular graph-based or convolutional autoencoders on point cloud or voxel data of 3D single cell masks as well as providing pre-trained networks for inference.

https://github.com/Sentinal4D/cellshape-voxel

Convolutional neural network

Cellshape-voxel is an easy-to-use tool to analyse the shapes of cells using deep learning and, in particular, 3D convolutional neural networks. The tool provides the ability to train 3D convolutional autoencoders on 3D single cell masks as well as providing pre-trained networks for inference.

Point cloud generation

https://github.com/Sentinal4D/cellshape-helper

Fig 1: cellshape workflow

For developers

  • Fork the repository
  • Clone your fork
git clone https://github.com/USERNAME/cellshape-cloud 
  • Install an editable version (-e) with the development requirements (dev)
cd cellshape-cloud
pip install -e .[dev] 
  • To install pre-commit hooks to ensure formatting is correct:
pre-commit install
  • To release a new version:

Firstly, update the version with bump2version (bump2version patch, bump2version minor or bump2version major). This will increment the package version (to a release candidate - e.g. 0.0.1rc0) and tag the commit. Push this tag to GitHub to run the deployment workflow:

git push --follow-tags

Once the release candidate has been tested, the release version can be created with:

bump2version release

References

[1] An Tao, 'Unsupervised Point Cloud Reconstruction for Classific Feature Learning', GitHub Repo, 2020

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