DendroTweaks

DendroTweaks is a Python toolbox designed for creating and validating single-cell biophysical models with active dendrites.

It is available both as a standalone Python package and a web-based application.

Learn More

• Standalone Library: Explore the official documentation for detailed tutorials and API reference.
• Web Application: Access the GUI online via our platform at dendrotweaks.dendrites.gr.
• Quick Overview: Check out our e-poster, including a video demonstration, presented at the FENS Forum 2024 in Vienna.
• Latest News: Follow us on Bluesky for updates.

Publication

For an in-depth understanding of DendroTweaks, refer to our publication in eLife:

Roman Makarov, Spyridon Chavlis, Panayiota Poirazi (2025).
DendroTweaks, an interactive approach for unraveling dendritic dynamics.
eLife 13:RP103324. https://doi.org/10.7554/eLife.103324.3

If you find DendroTweaks helpful for your research, please consider citing our work:

@article {Makarov2025,
    article_type = {journal},
    title = {DendroTweaks, an interactive approach for unraveling dendritic dynamics},
    author = {Makarov, Roman and Chavlis, Spyridon and Poirazi, Panayiota},
    volume = 13,
    year = 2025,
    month = {dec},
    pub_date = {2025-12-23},
    pages = {RP103324},
    citation = {eLife 2025;13:RP103324},
    doi = {10.7554/eLife.103324},
    url = {https://doi.org/10.7554/eLife.103324},
    journal = {eLife},
    issn = {2050-084X},
    publisher = {eLife Sciences Publications, Ltd},
}

License

This project uses multiple licenses depending on the content:

• Library code (src/dendrotweaks/*.py): Mozilla Public License 2.0 (MPL-2.0).
  All modifications to these files must remain under MPL-2.0 when redistributed.

• Documentation (docs/): Creative Commons Attribution 4.0 (CC-BY-4.0).
  You are free to copy, modify, and distribute the documentation, with attribution.

• Examples (examples/): no formal license; provided for demonstration purposes.
  Use freely in your own projects.

• Templates (src/dendrotweaks/biophys/default_templates): no formal license (permissive). You may reuse, modify, or include them in your projects freely.

• Third-party or model files (*.mod): license may vary or be unknown; see individual files.

Note: Previous versions of this project (before version 0.5.0) were released under GPL-3.0. This relicensing applies to releases from v0.5.0 onward.