Complete splicing and labeling quantification from metabolic labeling scRNA-seq
Project description
Dynast: Inclusive and efficient quantification of labeling and splicing RNAs for time-resolved metabolic labeling based scRNA-seq experiments
Getting started - Pipeline usage - Technical information - Full documentation
Dynast is a command-line pipeline that preprocesses data from metabolic labeling scRNA-seq experiments and quantifies the following four mRNA species: unlabeled unspliced, unlabeled spliced, labeled unspliced and labeled spliced. In addition, dynast can perform statistical estimation of these species through expectation maximization (EM) and Bayesian inference.
Key features
- Complete quantification of labeling and splicing of RNA.
- Unlabeled unspliced, unlabeled spliced, labeled unspliced, labeled spliced species quantification.
- Highly paralellized and optimized pipeline procedures.
- Statistical estimation procedure that corrects the observed unlabeled and labeled counts via a Bayesian inference framework.
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