enrich-omics 0.0.1

Package to perform enrichment analysis in python using EnrichR and OpenTargets APIs

ApplePy

Python wrapper for EnrichR and OpenTargets API. Allows for visualisation of pathways enriched and disease associated to a given target or disease

EnrichR

• Choose from all EnrichR libraries (Transcription, Pathways, Drugs, etc). Default library is "KEGG_pathways_2021"
• Get table with enrichment results
• Get plot with enrichment results

OpenTargets

Open Target is currently only supporting the search of a single target

Target endpoint

• Convert Entrez to Ensemble if needed (OpenTargets API accepts only Ensemble IDs)
• Get description of the function of the target
• Get diseases associated to a certain target
• Plot diseases associated to a certain target
• Get table drugs associated to a certain target
• Plot the drugs that work for a given target and the diseases associated to it
• Plot the drugs associated to a given target and the trial phase they are currently in

Drug endpoint

• Get drug description
• Get a table with drug information (year of approval, drug type, toxicity, warnings)

Plots

• Export plots in SVG and PNG