nqdc 0.0.2

Download neuroimaging articles and extract text and stereotactic coordinates.

NeuroQuery Data Collection

nqdc is a command-line tool for collecting data for large-scale coordinate-based neuroimaging meta-analysis. It exposes some of the machinery that was used to create the neuroquery dataset, which powers neuroquery.org.

nqdc downloads full-text articles from PubMed Central and extracts their text and stereotactic coordinates. It also computes TFIDF features for the extracted text.

Besides the command-line interface, nqdc's functionality is also exposed through its Python API.

Installation

You can install nqdc by running:

pip install nqdc

This will install the nqdc Python package, as well as the nqdc command.

Quick Start

Once nqdc is installed, we can download and process neuroimaging articles so that we can later use them for meta-analysis.

nqdc run ./nqdc_data -q "fMRI[title]"

See nqdc run --help for a description of this command. In particular, the --n_jobs option allows running the data extraction in parallel, which can significantly speed up the pipeline.

Usage

The creation of a dataset happens in four steps:

• Downloading the articles in bulk from the PMC API.
• Extracting the articles from the bulk download
• Extracting text, stereotactic coordinates and metadata from the articles, and storing this information in CSV files.
• Vectorizing the text: transforming it into vectors of TFIDF features.

Each of these steps stores its output in a separate directory. Normally, you will run the whole procedure in one command by invoking nqdc run. However, separate commands are also provided to run each step separately. Below, we describe each step and its output. Use nqdc -h to see a list of all available commands and nqdc run -h to see all the options of the main command.

All articles downloaded by nqdc come from PubMed Central, and are therefore identified by their PubMed Central ID (pmcid). Note this is not the same as the PubMed ID (pmid). Not all articles in PMC have a pmid.

Step 1: Downloading articles from PMC

This step is executed by the nqdc download command.

We must first define our query, with which Pubmed Central will be searched for articles. It can be simple such as fMRI, or more specific such as fMRI[Abstract] AND (2000[PubDate] : 2022[PubDate]). You can build the query using the PMC advanced search interface. For more information see the E-Utilities help. Some examples are provided in the nqdc git repository, in docs/example_queries.

The query can be passed either as a string on the command-line or by passing the path of a text file containing the query.

If we have an Entrez API key (see details in the E-utilities documentation), we can provide it through the NQDC_API_KEY environment variable or through the --api_key command line argument (the latter has higher precedence).

We must also specify the directory in which all nqdc data will be stored. It can be provided either as a command-line argument (as in the examples below), or by exporting the NQDC_DATA_DIR environment variable. Subdirectories will be created for each different query. In the following we suppose we are storing our data in a directory called nqdc_data.

We can thus download all articles with "fMRI" in their title published in 2019 by running:

nqdc download -q "fMRI[Title] AND (2019[PubDate] : 2019[PubDate])" nqdc_data

---

Note: writing the query in a file rather than passing it as an argument is more convenient for complex queries, for example those that contain whitespace, newlines or quotes. By storing it in a file we do not need to take care to quote or escape characters that would be interpreted by the shell. In this case we would store our query in a file, say query.txt:

fMRI[Title] AND (2019[PubDate] : 2019[PubDate])

and run

nqdc download -f query.txt nqdc_data

---

After running this command, these are the contents of our data directory:

· nqdc_data
  └── query-3c0556e22a59e7d200f00ac8219dfd6c
      └── articlesets
          ├── articleset_00000.xml
          └── info.json

nqdc has created a subdirectory for this query. If we run the download again for the same query, the same subdirectory will be reused (3c0556e22a59e7d200f00ac8219dfd6c is the md5 checksum of the query).

Inside the query directory, the results of the bulk download are stored in the articlesets directory. The articles themselves are in XML files bundling up to 500 articles called articleset_*.xml. Here there is only one because the search returned less than 500 articles.

Some information about the download is stored in info.json. In particular, is_complete indicates if all articles matching the search have been downloaded. If the download was interrupted, some batches failed to download, or the number of results was limited by using the --n_docs parameter, is_complete will be false and the exit status of the program will be 1. You may want to re-run the command before moving on to the next step if the download is incomplete.

If we run the same query again, only missing batches will be downloaded. If we want to force re-running the search and downloading the whole data we need to remove the articlesets directory.

Step 2: extracting articles from bulk download

This step is executed by the nqdc extract_articles command.

Once our download is complete, we extract articles directory and store them in individual XML files. To do so, we pass the articlesets directory created by the nqdc download command in step 1:

nqdc extract_articles nqdc_data/query-3c0556e22a59e7d200f00ac8219dfd6c/articlesets

This creates an articles subdirectory in the query directory, containing the articles. To avoid having a large number of files in a single directory when there are many articles, which can be problematic on some filesystems, the articles are spread over many subdirectories. The names of these subdirectories range from 000 to fff and an article goes in the subdirectory that matches the first 3 hexidecimal digits of the md5 hash of its pmcid.

Our data directory now looks like:

· nqdc_data
  └── query-3c0556e22a59e7d200f00ac8219dfd6c
      ├── articlesets
      │   ├── articleset_00000.xml
      │   └── info.json
      └── articles
          ├── 019
          │   └── pmcid_6759467.xml
          ├── 01f
          │   └── pmcid_6781806.xml
          ├── 03f
          │   └── pmcid_6625472.xml
          ├── ...
          ├── 27d
          │   ├── pmcid_6657681.xml
          │   └── pmcid_6790327.xml
          ├── ...
          │
          └── info.json

If the download and article extraction were successfully run and we run the same query again, the article extraction is skipped. If we want to force re-running the article extraction we need to remove the articles directory (or the info.json file it contains).

Step 3: extracting data from articles

This step is executed by the nqdc extract_data command.

It creates another directory that contains CSV files, containing the text, metadata and coordinates extracted from all the articles.

If we use the --articles_with_coords_only option, only articles in which nqdc finds stereotactic coordinates are kept. The name of the resulting directory will reflect that choice.

We pass the path of the articles directory created by nqdc extract_articles in the previous step to the nqdc extract_data command:

nqdc extract_data --articles_with_coords_only nqdc_data/query-3c0556e22a59e7d200f00ac8219dfd6c/articles/

Our data directory now contains (ommitting the contents of the previous steps):

· nqdc_data
  └── query-3c0556e22a59e7d200f00ac8219dfd6c
      ├── articles
      ├── articlesets
      └── subset_articlesWithCoords_extractedData
          ├── authors.csv
          ├── coordinates.csv
          ├── coordinate_space.csv
          ├── info.json
          ├── metadata.csv
          └── text.csv

If we had not used --articles_with_coords_only, the new subdirectory would be named subset_allArticles_extractedData instead.

• metadata.csv contains one row per article, with some metadata: pmcid (PubMed Central ID), pmid (PubMed ID), doi, title, journal, publication_year and license. Note some values may be missing (for example not all articles have a pmid or doi).
• authors.csv contains one row per article per author. Fields are pmcid, surname, given-names.
• text.csv contains one row per article. The first field is the pmcid, and the other fields are title, keywords, abstract, and body, and contain the text extracted from these parts of the article.
• coordinates.csv contains one row for each (x, y, z) stereotactic coordinate found in any article. Its fields are the pmcid of the article, the table label and id the coordinates came from, and x, y, z.
• coordinate_space.csv has fields pmcid and coordinate_space. It contains a guess about the stereotactic space coordinates are reported in, based on a heuristic derived from neurosynth. Possible values for the space are the terms used by neurosynth: "MNI", "TAL" (for Talairach space), and "UNKNOWN".

The different files can be joined on the pmcid field.

If all steps up to data extraction were successfully run and we run the same query again, the data extraction is skipped. If we want to force re-running the data extraction we need to remove the corresponding directory (or the info.json file it contains).

Step 4: vectorizing (computing TFIDF features)

This step is executed by the nqdc vectorize command.

Some large-scale meta-analysis methods such as neurosynth and neuroquery rely on TFIDF features to represent articles' text. The last step before we can apply these methods is therefore to extract TFIDF features from the text we obtained in the previous step.

TFIDF features rely on a predefined vocabulary (set of terms or phrases). Each dimension of the feature vector corresponds to a term in the vocabulary and represents the importance of that term in the encoded text. This importance is an increasing function of the term frequency (the number of time the term occurs in the text divided by the length of the text) and a decreasing function of the document frequency (the total number of times the term occurs in the whole corpus or dataset).

To extract the TFIDF features we must therefore choose a vocabulary.

• By default, nqdc will download and use the vocabulary used by neuroquery.org.
• If we use the --extract_vocabulary option, a new vocabulary is created from the downloaded text and used for computing TFIDF features (see "extracting a new vocabulary" below).
• If we want to use a different vocabulary we can specify it with the --vocabulary_file option. This file will be parsed as a CSV file with no header, whose first column contains the terms. Other columns are ignored.

We also pass to nqdc vectorize the directory containing the text we want to vectorize, created by nqdc extract_data in step 3 (here we are using the default vocabulary):

nqdc vectorize nqdc_data/query-3c0556e22a59e7d200f00ac8219dfd6c/subset_articlesWithCoords_extractedData/

This creates a new directory whose name reflects the data source (whether all articles are kept or only those with coordinates) and the chosen vocabulary (e6f7a7e9c6ebc4fb81118ccabfee8bd7 is the md5 checksum of the contents of the vocabulary file, concatenated with those of the vocabulary mapping file, see "vocabulary mapping" below):

· nqdc_data
  └── query-3c0556e22a59e7d200f00ac8219dfd6c
      ├── articles
      ├── articlesets
      ├── subset_articlesWithCoords_extractedData
      └── subset_articlesWithCoords-voc_e6f7a7e9c6ebc4fb81118ccabfee8bd7_vectorizedText
          ├── abstract_counts.npz
          ├── abstract_tfidf.npz
          ├── body_counts.npz
          ├── body_tfidf.npz
          ├── feature_names.csv
          ├── info.json
          ├── keywords_counts.npz
          ├── keywords_tfidf.npz
          ├── merged_tfidf.npz
          ├── pmcid.txt
          ├── title_counts.npz
          ├── title_tfidf.npz
          ├── vocabulary.csv
          └── vocabulary.csv_voc_mapping_identity.json

The extracted features are stored in .npz files that can be read for example with scipy.sparse.load_npz.

These files contain matrices of shape (n_docs, n_features), where n_docs is the number of documents and n_features the number of terms in the vocabulary. The pmcid corresponding to each row is found in pmcid.txt, and the term corresponding to each column is found in the first column of feature_names.csv.

feature_names.csv has no header; the first column contains terms and the second one contains their document frequency.

For each article part ("title", "keywords", "abstract" and "body"), we get the counts which hold the raw counts (the number of times each word occurs in that section), and the tfidf which hold the TFIDF features (the counts divided by article length and log document frequency). Moreover, merged_tfidf contains the mean TFIDF computed across all article parts.

If all steps up to vectorization were successfully run and we run the same query again, the vectorization is skipped. If we want to force re-running the vectorization we need to remove the corresponding directory (or the info.json file it contains).

Vocabulary mapping: collapsing redundant words

It is possible to instruct the tokenizer (that extracts words from text) to collapse some pairs of terms that have the same meaning but different spellings, such as "brainstem" and "brain stem".

This is done through a JSON file that contains a mapping of the form {term: replacement}. For example if it contains {"brain stem": "brainstem"}, "brain stem" will be discarded from the vocabulary and every occurrence of "brain stem" will be counted as an occurrence of "brainstem" instead. To be found by nqdc, this vocabulary mapping file must be in the same directory as the vocabulary file, and its name must be the vocabulary file's name with _voc_mapping_identity.json appended: for example vocabulary.csv, vocabulary.csv_voc_mapping_identity.json.

When a vocabulary mapping is provided, a shorter vocabulary is therefore created by removing redundant words. The TFIDF and word counts computed by nqdc correspond to the shorter vocabulary, which is stored along with its document frequencies in feature_names.csv.

vocabulary.csv contains the document frequencies of the original (full, longer) vocabulary. A vocabulary.csv_voc_mapping_identity.json file is always created by nqdc, but if no vocabulary mapping was used, that file contains an empty mapping ({}) and vocabulary.csv and feature_names.csv are identical.

The vocabulary mapping is primarily used by the neuroquery package and its tokenization pipeline, and you can safely ignore this – just remember that the file providing the terms corresponding to the TFIDF features is feature_names.csv.

Optional step: extracting a new vocabulary

This step is executed by the nqdc extract_vocabulary command. When running the full pipeline this step is optional: we must use the --extract_vocabulary option for it to be executed.

It builds a vocabulary of all the words and 2-grams (groups of 2 words) that appear in the downloaded text, and computes their document frequency (the proportion of documents in which a term appears).

nqdc extract_vocabulary nqdc_data/query-3c0556e22a59e7d200f00ac8219dfd6c/subset_articlesWithCoords_extractedData

The vocabulary is stored in a csv file in a new directory. There is no header and the 2 columns are the term and its document frequency.

· nqdc_data
  └── query-3c0556e22a59e7d200f00ac8219dfd6c
      ├── articles
      ├── articlesets
      ├── subset_articlesWithCoords_extractedData
      ├── subset_articlesWithCoords_extractedVocabulary
      │   ├── info.json
      │   └── vocabulary.csv
      └── subset_articlesWithCoords-voc_e6f7a7e9c6ebc4fb81118ccabfee8bd7_vectorizedText

When running the whole pipeline (nqdc run), if we use the --extract_vocabulary option and do not provide an explicit value for --vocabulary_file, the freshly-extracted vocabulary is used instead of the default neuroquery one for computing TFIDF features.

Optional step: fitting a NeuroQuery encoding model

This step is executed by the nqdc fit_neuroquery command. When running the full pipeline it is optional: we must use the --fit_neuroquery option for it to be executed.

In this step, once the TFIDF features and the coordinates have been extracted from downloaded articles, they are used to train a NeuroQuery encoding model -- the same type of model that is exposed at neuroquery.org. Details about this model are provided in the NeuroQuery paper and the documentation for the neuroquery package.

Note: for this model to give good results a large dataset is needed, ideally close to 10,000 articles (with coordinates).

We pass the _vectorizedText directory created by nqdc vectorize:

nqdc fit_neuroquery nqdc_data/query-3c0556e22a59e7d200f00ac8219dfd6c/subset_articlesWithCoords-voc_e6f7a7e9c6ebc4fb81118ccabfee8bd7_vectorizedText

This creates a directory whose name ends with _neuroqueryModel:

· nqdc_data
  └── query-3c0556e22a59e7d200f00ac8219dfd6c
      ├── articles
      ├── articlesets
      ├── subset_articlesWithCoords_extractedData
      ├── subset_articlesWithCoords-voc_e6f7a7e9c6ebc4fb81118ccabfee8bd7_neuroqueryModel
      │   ├── app.py
      │   ├── info.json
      │   ├── neuroquery_model
      │   │   ├── corpus_metadata.csv
      │   │   ├── corpus_tfidf.npz
      │   │   ├── mask_img.nii.gz
      │   │   ├── regression
      │   │   │   ├── coef.npy
      │   │   │   ├── intercept.npy
      │   │   │   ├── M.npy
      │   │   │   ├── original_n_features.npy
      │   │   │   ├── residual_var.npy
      │   │   │   └── selected_features.npy
      │   │   ├── smoothing
      │   │   │   ├── smoothing_weight.npy
      │   │   │   └── V.npy
      │   │   ├── vocabulary.csv
      │   │   └── vocabulary.csv_voc_mapping_identity.json
      │   ├── README.md
      │   └── requirements.txt
      └── subset_articlesWithCoords-voc_e6f7a7e9c6ebc4fb81118ccabfee8bd7_vectorizedText

You do not need to care about the contents of the neuroquery_model subdirectory, that is data used by the neuroquery package. Just know that it can be used to initialize a neuroquery.NeuroQueryModel with:

from neuroquery import NeuroQueryModel
model = NeuroQueryModel.from_data_dir("neuroquery_model")

The neuroquery documentation provides information and examples on how to use this model.

Visualizing the newly trained model in an interactive web page

It is easy to interact with the model through a small web (Flask) application. From inside the [...]_neuroqueryModel directory, just run pip install -r requirements.txt to install flask, nilearn and neuroquery. Then run flask run and point your web browser to https://localhost:5000: you can play with a local, simplified version of neuroquery.org built with the data we just downloaded.

Optional step: running a NeuroSynth meta-analysis

This step is executed by the nqdc fit_neurosynth command. When running the full pipeline it is optional: we must use the --fit_neurosynth option for it to be executed.

In this step, once the TFIDF features and the coordinates have been extracted from downloaded articles, they are used to run meta-analyses using NeuroSynth's "association test" method: a Chi-squared test of independence between voxel activation and term occurrences. See the NeuroSynth paper and neurosynth.org, as well as the neurosynth and NiMARE documentation pages for more information.

We pass the _vectorizedText directory created by nqdc vectorize:

nqdc fit_neurosynth nqdc_data/query-3c0556e22a59e7d200f00ac8219dfd6c/subset_articlesWithCoords-voc_e6f7a7e9c6ebc4fb81118ccabfee8bd7_vectorizedText

This creates a directory whose name ends with _neurosynthResults:

· nqdc_data
  └── query-3c0556e22a59e7d200f00ac8219dfd6c
      ├── articles
      ├── articlesets
      ├── subset_articlesWithCoords_extractedData
      ├── subset_articlesWithCoords-voc_e6f7a7e9c6ebc4fb81118ccabfee8bd7_neurosynthResults
      │   ├── app.py
      │   ├── info.json
      │   ├── metadata.csv
      │   ├── neurosynth_maps
      │   │   ├── aberrant.nii.gz
      │   │   ├── abilities.nii.gz
      │   │   ├── ability.nii.gz
      │   │   └── ...
      │   ├── README.md
      │   ├── requirements.txt
      │   ├── terms.csv
      │   └── tfidf.npz
      └── subset_articlesWithCoords-voc_e6f7a7e9c6ebc4fb81118ccabfee8bd7_vectorizedText

The meta-analytic maps for all the terms in the vocabulary can be found in the neurosynth_maps subdirectory.

Visualizing the meta-analytic maps in an interactive web page

It is easy to interact with the NeuroSynth maps through a small web (Flask) application. From inside the [...]_neurosynthResults directory, just run pip install -r requirements.txt to install flask and other dependencies. Then run flask run and point your web browser to https://localhost:5000: you can search for a term and see the corresponding brain map and the documents that mention it.

Optional step: preparing articles for annotation with labelbuddy

This step is executed by the nqdc extract_labelbuddy_data command. When running the full pipeline this step is optional: we must use the --labelbuddy or --labelbuddy_part_size option for it to be executed.

It prepares the articles whose data was extracted for annotation with labelbuddy.

We pass the _extractedData directory created by nqdc extract_data:

nqdc extract_labelbuddy_data nqdc_data/query-3c0556e22a59e7d200f00ac8219dfd6c/subset_articlesWithCoords_extractedData

This creates a directory whose name ends with labelbuddyData containing the batches of documents in JSONL format (in this case there is a single batch):

· nqdc_data
  └── query-3c0556e22a59e7d200f00ac8219dfd6c
      ├── articles
      ├── articlesets
      ├── subset_articlesWithCoords_extractedData
      ├── subset_articlesWithCoords_labelbuddyData
      │   ├── documents_00001.jsonl
      │   └── info.json
      └── subset_articlesWithCoords-voc_e6f7a7e9c6ebc4fb81118ccabfee8bd7_vectorizedText

The documents can be imported into labelbuddy using the GUI or with:

labelbuddy mydb.labelbuddy --import-docs documents_00001.jsonl

See the labelbuddy documentation for details.

Optional step: creating a NiMARE dataset

This step is executed by the nqdc extract_nimare_data command. When running the full pipeline this step is optional: we must use the --nimare option for it to be executed.

It creates a NiMARE dataset for the extracted data in JSON format. See the NiMARE documentation for details.

We pass the _vectorizedText directory created by nqdc vectorize:

nqdc extract_nimare_data nqdc_data/query-3c0556e22a59e7d200f00ac8219dfd6c/subset_articlesWithCoords-voc_e6f7a7e9c6ebc4fb81118ccabfee8bd7_vectorizedText

The resulting directory contains a nimare_dataset.json file that can be used to initialize a nimare.Dataset.

· nqdc_data
  └── query-3c0556e22a59e7d200f00ac8219dfd6c
      ├── articles
      ├── articlesets
      ├── subset_articlesWithCoords_extractedData
      ├── subset_articlesWithCoords-voc_e6f7a7e9c6ebc4fb81118ccabfee8bd7_nimareDataset
      │   ├── info.json
      │   └── nimare_dataset.json
      └── subset_articlesWithCoords-voc_e6f7a7e9c6ebc4fb81118ccabfee8bd7_vectorizedText

Using this option requires installing NiMARE, which is not installed by default with nqdc. To use this option, install NiMARE separately with

pip install nimare

or install nqdc with

pip install "nqdc[nimare]"

Full pipeline

We can run all steps in one command by using nqdc run.

The full procedure described above could be run by executing:

nqdc run -q "fMRI[Title] AND (2019[PubDate] : 2019[PubDate])" \
    --articles_with_coords_only                               \
    nqdc_data

(The output directory, nqdc_data, could also be provided by exporting the NQDC_DATA_DIR environment variable instead of passing it on the command line.)

If we also want to apply the optional steps:

nqdc run -q "fMRI[Title] AND (2019[PubDate] : 2019[PubDate])" \
    --articles_with_coords_only                               \
    --fit_neuroquery                                          \
    --labelbuddy                                              \
    --nimare                                                  \
    nqdc_data

(remember that --nimare requires NiMARE to be installed).

Here also, steps that had already been completed are skipped; we need to remove the corresponding directories if we want to force running these steps again.

See nqdc run --help for a description of all options.

Logging

By default nqdc commands report their progress by writing to the standard streams. In addition, they can write log files if we provide the --log_dir command-line argument, or if we define the NQDC_LOG_DIR environment variable (the command-line argument has higher precedence). If this log directory is specified, a new log file with a timestamp is created and all the output is written there as well.

Writing plugins

It is possible to write plugins and define entry points to add functionality that is automatically executed when nqdc is run.

The name of the entry point should be nqdc.plugin_processing_steps. It must be a function taking no arguments and returning a dictionary with keys pipeline_steps and standalone_steps. The corresponding values must be lists of processing step objects, that must implement the interface defined by nqdc.BaseProcessingStep (their types do not need to inherit from nqdc.BaseProcessingStep).

All steps in pipeline_steps will be run when nqdc run is used. All steps in standalone_steps will be added as additional nqdc commands; for example if the name of a standalone step is my_plugin, the nqdc my_plugin command will become available.

An example plugin that can be used as a template, and more details, are provided in the nqdc git repository, in docs/example_plugin.

Contributing

Feedback and contributions are welcome. Development happens at the nqdc GitHub repositiory. To install the dependencies required for development, from the directory where you cloned nqdc, run:

pip install -e ".[dev]"

The tests can be run with make test_all, or make test_coverage to report test coverage. The documentation can be rendered with make doc. make run_full_pipeline runs the full nqdc pipeline on a query returning a realistic number of results (fMRI[title]).

Python API

nqdc is mostly intended for use as a command-line tool. However, it is also a Python package and its functionality can be used in Python programs. The Python API closely reflects the command-line programs described above.

The Python API is described on the nqdc website.

nqdc releases

0.0.2

• Changes to the command-line interface; now all in one command nqdc; nqdc_full_pipeline becomes nqdc run.

• Add several commands/steps:

  • Creating a NiMARE dataset.
  • Preparing documents for annotation with labelbuddy.
  • Extracting a new vocabulary.
  • Fitting neuroquery.
  • Running neurosynth analysis.
  • Possibility to create plugins.

• Parallelize data extraction; several improvements to text & coordinate extraction

0.0.1

First release; tentative API for downloading PMC data, extracting articles, extracting data, and vectorizing text.

MIT License

Copyright (c) 2022 Jérôme Dockès

Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software.

THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.