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AlphaImpute2

AlphaImpute2 is a phasing and imputation algorithm for massive livestock populations. The method uses a approximate version of multi-locus iterative peeling for pedigree based imputation, and a novel imputation algorithm that uses the Positional Burrows Wheeler Transform for population imputation. AlphaImpute2 has been successfully used to perform imputation in populations of hundreds of thousands of individuals. AlphaImpute2 was developed by Andrew Whalen, and is currently being supported by Andrew Whalen and Steve Thorn.

User guide

See https://alphapeel.readthedocs.io/en/latest

Installation

AlphaImpute2 is available on PyPI:

pip install AlphaImpute2

Example

An example dataset and corresponding script are available in the example/ folder.

Conditions of use

AlphaImpute2 is part of a suite of software that our group has developed. It is fully and freely available for all use under the MIT License.

Suggested Citation

Whalen, A, J.M. Hickey, (2020), AlphaImpute2: Fast and accurate pedigree and population based imputation for hundreds of thousands of individuals in livestock populations, bioRxiv.https://doi.org/10.1101/2020.09.16.299677

Metadata

Release files for AlphaImpute2 0.0.5

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