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Bering: Transfer Learning of Cell Segmentation and Annotation for Spatial Omics

Project description

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Bering - Spatial Segmentation and Cell Annotation in Python

Bering is a deep learning algorithm for simultaneous molecular annotation and cell segmentation in single-cell spatial transcriptomics data. It builds on top of torch_geometric_ and scanpy_, from which it inherits modularity and scalability. It provides versatile models that leverages the spatial coordinates of the data, as well as pre-trained models across spatial technologies and tissues.

Visit our documentation_ for installation, tutorials, examples and more.

Bering's key applications

  • Identify background and real signals in noisy spatial transcriptomics data.
  • Identify cell annotations for transcripts on single-cell spatial data.
  • Efficiently cell segmentation with cell annotations.
  • Build and fine-tune pre-trained model on new data using transfer learning.

Installation

Install Bering via PyPI by running::

pip install Bering

or via Conda as::

conda install -c conda-forge Bering

Manuscript

Please refer to our manuscript Jin, Zhang et al. (2023)_ for more details.

Contact

We are happy about any feedback! If you have any questions, please feel free to contact kangjin@fas.harvard.edu, zuobai.zhang@mila.quebec. Find more research in Shu_Jian_Lab_.

.. |PyPI| image:: https://img.shields.io/pypi/v/Bering :target: https://pypi.org/project/Bering/ :alt: PyPI

.. |Docs| image:: https://img.shields.io/readthedocs/bering :target: https://bering.readthedocs.io/en/latest/ :alt: Documentation

.. |downloads| image:: https://img.shields.io/pepy/dt/Bering :target: https://www.pepy.tech/projects/Bering :alt: Downloads

.. _Jin, Zhang et al. (2023): https://www.biorxiv.org/content/10.1101/2023.09.19.558548v1 .. _scanpy: https://scanpy.readthedocs.io/en/stable/ .. _torch_geometric: https://pytorch-geometric.readthedocs.io/en/latest/ .. _documentation: https://bering.readthedocs.io/en/latest/ .. _Shu_Jian_Lab: https://www.jianshulab.org/team

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