QuickEd

QuickEd is a high-performance exact sequence alignment library based on the bound-and-align paradigm. Currently, QuickEd focuses on DNA sequence alignment (A, C, G, T, N), using the edit distance (Levenshtein distance) metric.

from quicked import QuickedAligner, QuickedException

pattern = "ACGT" # Pattern sequence
text = "ACTT"    # Text sequence
score = -1       # Alignment score
cigar = ""       # CIGAR string

try:
    aligner = QuickedAligner()    # Aligner object, with sensible default parameters
    # Without any extra configuration, the aligner will use the Quicked algorithm

    aligner.align(pattern, text)  # Align the sequences!

    score = aligner.getScore()    # Get the score
    cigar = aligner.getCigar()    # Get the CIGAR string
except QuickedException as e:
    print(e)

print(f"Score: {score}") # Print the score
print(f"Cigar: {cigar}") # Print the CIGAR string

QuickEd is actually a C library, and this package is it’s wrapper for Python. Check out QuickEd's GitHub for more code examples and more details on how QuickEd works.

Features

Calculates edit distance (Levenshtein distance).
It can find optimal alignment path (instructions on how to transform the first sequence into the second sequence).
Supports multiple alignment algorithms:
- QuickEd
- BandEd
- WindowEd
Efficient implementation of the bound-and-align paradigm.
It scales to long and noisy sequences, even when finding an alignment path, while consuming very little memory thanks to the Hirschberg algorithm.

IMPORTANT! As QuickEd focuses on DNA sequence alignment, expected alphabet characters are limited to A, C, G, T, and N. However, no check is performed on the input sequences for performance reasons.

Installation

PyPI

QuickEd is available on PyPI, so you can install it using pip:

pip install quicked

Conda

Conda support is still in progress.

From source

To install the Python bindings from source, you can simply run pip install . from the root directory of the QuickEd repository. This will build and install the bindings for your current Python environment.

API

Take a look at basic.py for a minimal example.

QuickedAlgo

Enum that defines the alignment algorithm to use. The available algorithms are:

QUICKED: QuickEd algorithm (default)
BANDED: BandEd algorithm
WINDOWED: WindowEd algorithm
HIRSCHBERG: Hirschberg algorithm

QuickedAligner

This class defines an aligner object that can be used to perform sequence alignment. It is initialized with default parameters and can be configured using various setter methods.

aligner = QuickedAligner()

`align(pattern, text)`

Aligns the provided pattern and text according to the current parameters.

Parameters:
- pattern (str): The pattern to be aligned.
- text (str): The text to be aligned against.

`setAlgorithm(algorithm)`

Sets the algorithm to be used for alignment.

Parameters:
- algorithm (QuickedAlgo): The alignment algorithm to use.

`setOnlyScore(only_score)`

Sets whether only the score should be computed.

Parameters:
- only_score (bool): A boolean indicating if only the score should be computed.

`setBandwidth(bandwidth)`

Sets the bandwidth for BandEd alignment.

Parameters:
- bandwidth (int): The bandwidth value to set.

`setWindowSize(window_size)`

Sets the window size for WindowEd alignment.

Parameters:
- window_size (int): The window size value to set.

`setOverlapSize(overlap_size)`

Sets the overlap size for WindowEd alignment.

Parameters:
- overlap_size (int): The overlap size value to set.

`setForceScalar(force_scalar)`

Forces scalar computation (i.e., no SIMD instructions).

Parameters:
- force_scalar (bool): A boolean indicating whether to force scalar computation.

`setHEWThreshold(hew_threshold)`

Sets the HEW threshold.

Parameters:
- hew_threshold (float): The HEW threshold value to set.

`setHEWPercentage(hew_percentage)`

Sets the HEW percentage.

Parameters:
- hew_percentage (float): The HEW percentage value to set.

`getScore()`

Gets the alignment score.

Returns:
- (float): The alignment score as a numeric value.

`getCigar()`

Gets the CIGAR string representing the alignment.

Returns:
- (str): A string representing the alignment in CIGAR format.

Metadata

Release files for QuickEd 1.2

For a detailed explanation of source distributions (sdists) and built distributions (wheels), please see the package formats documentation.

Source distribution (sdist)

Source distribution for QuickEd 1.2
File	Size	Uploaded
quicked-1.2.tar.gz	5.3 MB	May 5, 2025	Details

Built distributions (wheels)

Table of built distributions (wheels) for QuickEd 1.2
File	Interpreter	ABI	Platform	Reset
quicked-1.2-cp313-cp313-win_amd64.whl 195.8 kB May 5, 2025	CPython 3.13	CPython 3.13	Windows x86-64	Details
quicked-1.2-cp313-cp313-manylinux_2_17_x86_64.manylinux2014_x86_64.whl 310.1 kB May 5, 2025	CPython 3.13	CPython 3.13	Linux glibc 2.17+ x86-64	Details
quicked-1.2-cp313-cp313-macosx_11_0_arm64.whl 209.6 kB May 5, 2025	CPython 3.13	CPython 3.13	macOS 11.0+ ARM64	Details
quicked-1.2-cp313-cp313-macosx_10_13_x86_64.whl 243.7 kB May 5, 2025	CPython 3.13	CPython 3.13	macOS 10.13+ x86-64	Details
quicked-1.2-cp312-cp312-win_amd64.whl 195.7 kB May 5, 2025	CPython 3.12	CPython 3.12	Windows x86-64	Details
quicked-1.2-cp312-cp312-manylinux_2_17_x86_64.manylinux2014_x86_64.whl 310.2 kB May 5, 2025	CPython 3.12	CPython 3.12	Linux glibc 2.17+ x86-64	Details
quicked-1.2-cp312-cp312-macosx_11_0_arm64.whl 209.1 kB May 5, 2025	CPython 3.12	CPython 3.12	macOS 11.0+ ARM64	Details
quicked-1.2-cp312-cp312-macosx_10_13_x86_64.whl 243.6 kB May 5, 2025	CPython 3.12	CPython 3.12	macOS 10.13+ x86-64	Details
quicked-1.2-cp311-cp311-win_amd64.whl 196.7 kB May 5, 2025	CPython 3.11	CPython 3.11	Windows x86-64	Details
quicked-1.2-cp311-cp311-manylinux_2_17_x86_64.manylinux2014_x86_64.whl 313.5 kB May 5, 2025	CPython 3.11	CPython 3.11	Linux glibc 2.17+ x86-64	Details
quicked-1.2-cp311-cp311-macosx_11_0_arm64.whl 209.3 kB May 5, 2025	CPython 3.11	CPython 3.11	macOS 11.0+ ARM64	Details
quicked-1.2-cp311-cp311-macosx_10_9_x86_64.whl 244.1 kB May 5, 2025	CPython 3.11	CPython 3.11	macOS 10.9+ x86-64	Details
quicked-1.2-cp310-cp310-win_amd64.whl 194.0 kB May 5, 2025	CPython 3.10	CPython 3.10	Windows x86-64	Details
quicked-1.2-cp310-cp310-manylinux_2_17_x86_64.manylinux2014_x86_64.whl 310.3 kB May 5, 2025	CPython 3.10	CPython 3.10	Linux glibc 2.17+ x86-64	Details
quicked-1.2-cp310-cp310-macosx_11_0_arm64.whl 206.5 kB May 5, 2025	CPython 3.10	CPython 3.10	macOS 11.0+ ARM64	Details
quicked-1.2-cp310-cp310-macosx_10_9_x86_64.whl 241.8 kB May 5, 2025	CPython 3.10	CPython 3.10	macOS 10.9+ x86-64	Details
quicked-1.2-cp39-cp39-win_amd64.whl 193.8 kB May 5, 2025	CPython 3.9	CPython 3.9	Windows x86-64	Details
quicked-1.2-cp39-cp39-manylinux_2_17_x86_64.manylinux2014_x86_64.whl 310.8 kB May 5, 2025	CPython 3.9	CPython 3.9	Linux glibc 2.17+ x86-64	Details
quicked-1.2-cp39-cp39-macosx_11_0_arm64.whl 206.7 kB May 5, 2025	CPython 3.9	CPython 3.9	macOS 11.0+ ARM64	Details
quicked-1.2-cp39-cp39-macosx_10_9_x86_64.whl 241.9 kB May 5, 2025	CPython 3.9	CPython 3.9	macOS 10.9+ x86-64	Details
quicked-1.2-cp38-cp38-win_amd64.whl 193.5 kB May 5, 2025	CPython 3.8	CPython 3.8	Windows x86-64	Details
quicked-1.2-cp38-cp38-manylinux_2_17_x86_64.manylinux2014_x86_64.whl 310.3 kB May 5, 2025	CPython 3.8	CPython 3.8	Linux glibc 2.17+ x86-64	Details
quicked-1.2-cp38-cp38-macosx_11_0_arm64.whl 206.3 kB May 5, 2025	CPython 3.8	CPython 3.8	macOS 11.0+ ARM64	Details
quicked-1.2-cp38-cp38-macosx_10_9_x86_64.whl 241.3 kB May 5, 2025	CPython 3.8	CPython 3.8	macOS 10.9+ x86-64	Details

Total release size: 11.1 MB

Release files / quicked-1.2.tar.gz

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Size	195.8 kB
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Release files / quicked-1.2-cp312-cp312-win_amd64.whl

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Release files / quicked-1.2-cp312-cp312-manylinux_2_17_x86_64.manylinux2014_x86_64.whl

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Publishing commit: github.com/maxdoblas/QuickEd/tree/2b1d44b8204a17fa0752fbe0b69b081c86a56e10

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Publishing commit: github.com/maxdoblas/QuickEd/tree/2b1d44b8204a17fa0752fbe0b69b081c86a56e10

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Publishing commit: github.com/maxdoblas/QuickEd/tree/2b1d44b8204a17fa0752fbe0b69b081c86a56e10

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Publishing repository: github.com/maxdoblas/QuickEd
Publishing commit: github.com/maxdoblas/QuickEd/tree/2b1d44b8204a17fa0752fbe0b69b081c86a56e10

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Publishing commit: github.com/maxdoblas/QuickEd/tree/2b1d44b8204a17fa0752fbe0b69b081c86a56e10

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Publishing repository: github.com/maxdoblas/QuickEd
Publishing commit: github.com/maxdoblas/QuickEd/tree/2b1d44b8204a17fa0752fbe0b69b081c86a56e10

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Publishing repository: github.com/maxdoblas/QuickEd
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Publishing repository: github.com/maxdoblas/QuickEd
Publishing commit: github.com/maxdoblas/QuickEd/tree/2b1d44b8204a17fa0752fbe0b69b081c86a56e10

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Publishing repository: github.com/maxdoblas/QuickEd
Publishing commit: github.com/maxdoblas/QuickEd/tree/2b1d44b8204a17fa0752fbe0b69b081c86a56e10

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Publishing repository: github.com/maxdoblas/QuickEd
Publishing commit: github.com/maxdoblas/QuickEd/tree/2b1d44b8204a17fa0752fbe0b69b081c86a56e10

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Publishing platform: GitHub Actions
Publishing repository: github.com/maxdoblas/QuickEd
Publishing commit: github.com/maxdoblas/QuickEd/tree/2b1d44b8204a17fa0752fbe0b69b081c86a56e10

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Release history Release notifications | RSS feed

This release

1.2 This release

May 5, 2025 25 release files

QuickEd 1.2

QuickEd

Features

Installation

PyPI

Conda

From source

API

QuickedAlgo

QuickedAligner

align(pattern, text)

setAlgorithm(algorithm)

setOnlyScore(only_score)

setBandwidth(bandwidth)

setWindowSize(window_size)

setOverlapSize(overlap_size)

setForceScalar(force_scalar)

setHEWThreshold(hew_threshold)

setHEWPercentage(hew_percentage)

getScore()

getCigar()

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1 maintainer

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1 maintainer

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Release files for QuickEd 1.2

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Release files / quicked-1.2.tar.gz

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Release files / quicked-1.2-cp313-cp313-win_amd64.whl

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Release files / quicked-1.2-cp313-cp313-macosx_10_13_x86_64.whl

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PyPI Publish Attestation

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Workflow

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Release files / quicked-1.2-cp312-cp312-win_amd64.whl

Provenance

PyPI Publish Attestation

Identity

Workflow

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Release files / quicked-1.2-cp312-cp312-manylinux_2_17_x86_64.manylinux2014_x86_64.whl

`align(pattern, text)`

`setAlgorithm(algorithm)`

`setOnlyScore(only_score)`

`setBandwidth(bandwidth)`

`setWindowSize(window_size)`

`setOverlapSize(overlap_size)`

`setForceScalar(force_scalar)`

`setHEWThreshold(hew_threshold)`

`setHEWPercentage(hew_percentage)`

`getScore()`

`getCigar()`