Add your description here
Project description
MLM25: MaveDB Amino Acid Substitution Prediction
Summary
Understanding the functional consequences of genetic variants is a cornerstone of modern genomics. Multiplexed Assays of Variant Effect (MAVEs) provide high-throughput measurements of how thousands of variants impact gene function, and MaveDB is a growing repository of these datasets, but it is still expensive and time-consuming to experimentally test every variant. In this challenge, your task is to develop a machine learning model that can predict the functional outcomes of amino acid substitutions.
Sources/Citations
Rubin, A.F., Stone, J., Bianchi, A.H. et al. MaveDB 2024: a curated community database with over seven million variant effects from multiplexed functional assays. Genome Biol 26, 13 (2025). https://doi.org/10.1186/s13059-025-03476-y
ESM Team. "ESM Cambrian: Revealing the mysteries of proteins with unsupervised learning." EvolutionaryScale, 2024, https://evolutionaryscale.ai/blog/esm-cambrian.
Release history Release notifications | RSS feed
Download files
Download the file for your platform. If you're not sure which to choose, learn more about installing packages.
Source Distribution
Built Distribution
Filter files by name, interpreter, ABI, and platform.
If you're not sure about the file name format, learn more about wheel file names.
Copy a direct link to the current filters
File details
Details for the file aasp-0.1.1a1.tar.gz.
File metadata
- Download URL: aasp-0.1.1a1.tar.gz
- Upload date:
- Size: 2.3 kB
- Tags: Source
- Uploaded using Trusted Publishing? Yes
- Uploaded via: twine/6.1.0 CPython/3.13.7
File hashes
| Algorithm | Hash digest | |
|---|---|---|
| SHA256 |
5cbe0cc220c4e39523f0b281b98679061e54e24193957c4e36fcadaffb10c63e
|
|
| MD5 |
25457ff582079b577ea09d60fc2729d5
|
|
| BLAKE2b-256 |
cd8c70eec0cb2d75d6fda2382d8a2d8cf0552c32a5488cb1620196bd2ee3842c
|
Provenance
The following attestation bundles were made for aasp-0.1.1a1.tar.gz:
Publisher:
python-publish.yml on isaacdchu/mlm25_mavedb
-
Statement:
-
Statement type:
https://in-toto.io/Statement/v1 -
Predicate type:
https://docs.pypi.org/attestations/publish/v1 -
Subject name:
aasp-0.1.1a1.tar.gz -
Subject digest:
5cbe0cc220c4e39523f0b281b98679061e54e24193957c4e36fcadaffb10c63e - Sigstore transparency entry: 513328581
- Sigstore integration time:
-
Permalink:
isaacdchu/mlm25_mavedb@872bd5a74f42d85a0875e69d44dafc6088d4325a -
Branch / Tag:
refs/tags/v0.1.1-alpha.1 - Owner: https://github.com/isaacdchu
-
Access:
public
-
Token Issuer:
https://token.actions.githubusercontent.com -
Runner Environment:
github-hosted -
Publication workflow:
python-publish.yml@872bd5a74f42d85a0875e69d44dafc6088d4325a -
Trigger Event:
release
-
Statement type:
File details
Details for the file aasp-0.1.1a1-py3-none-any.whl.
File metadata
- Download URL: aasp-0.1.1a1-py3-none-any.whl
- Upload date:
- Size: 2.7 kB
- Tags: Python 3
- Uploaded using Trusted Publishing? Yes
- Uploaded via: twine/6.1.0 CPython/3.13.7
File hashes
| Algorithm | Hash digest | |
|---|---|---|
| SHA256 |
c8153fb44cd91171e8ec169545c35744570410561a334ab4693b3cfb70b2a44a
|
|
| MD5 |
8e507a4b3b822397788a91eefbe1866a
|
|
| BLAKE2b-256 |
453d354e09342bfc895ad86244a3feb7a305ddcdefd8d2faa8d72494d1d4b743
|
Provenance
The following attestation bundles were made for aasp-0.1.1a1-py3-none-any.whl:
Publisher:
python-publish.yml on isaacdchu/mlm25_mavedb
-
Statement:
-
Statement type:
https://in-toto.io/Statement/v1 -
Predicate type:
https://docs.pypi.org/attestations/publish/v1 -
Subject name:
aasp-0.1.1a1-py3-none-any.whl -
Subject digest:
c8153fb44cd91171e8ec169545c35744570410561a334ab4693b3cfb70b2a44a - Sigstore transparency entry: 513328596
- Sigstore integration time:
-
Permalink:
isaacdchu/mlm25_mavedb@872bd5a74f42d85a0875e69d44dafc6088d4325a -
Branch / Tag:
refs/tags/v0.1.1-alpha.1 - Owner: https://github.com/isaacdchu
-
Access:
public
-
Token Issuer:
https://token.actions.githubusercontent.com -
Runner Environment:
github-hosted -
Publication workflow:
python-publish.yml@872bd5a74f42d85a0875e69d44dafc6088d4325a -
Trigger Event:
release
-
Statement type:
