agingclockbench 0.2.0

Benchmark biological aging clocks on your data — PhenoAge, KDM, DunedinPACE proxy

AgingClockBench

Benchmark biological aging clocks on your data in minutes.

Multiple biological aging clocks exist — PhenoAge, KDM, DunedinPACE — but no standard tool lets researchers compare them side-by-side. AgingClockBench is the first open-source Python package implementing multiple clocks with a unified interface and reproducible mortality-validated benchmarking.

📖 Documentation & Examples

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Install

pip install agingclockbench

Requires Python 3.11+.

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Quick Start

from agingclockbench import PhenoAge, KDM, BenchmarkSuite
from agingclockbench.datasets import load_nhanes_sample

# Load bundled NHANES 1999-2000 (N=4,086, 20-year mortality follow-up)
df = load_nhanes_sample()

# Compute biological ages
results = {
    "PhenoAge": PhenoAge().transform(df),
    "KDM":      KDM().transform(df),
}

# Benchmark against mortality
suite = BenchmarkSuite(mortality_col="mortstat", followup_col="permth_exm")
report = suite.run(df, results)

print(report.to_dataframe())

Clock     Pearson r  Mort HR (per SD accel)  Mort p-value
PhenoAge      0.930                    1.83      0.000001
KDM           0.677                    1.41      0.000001

report.plot_km_survival()      # Kaplan-Meier by acceleration quartile
report.plot_comparison()       # biological age vs chronological age
report.to_html("report.html")  # interactive Plotly report

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CLI

# Benchmark on bundled NHANES with HTML report
agingclockbench benchmark --data bundled --clocks all --report

# Your own data
agingclockbench benchmark \
  --data my_cohort.csv \
  --clocks PhenoAge KDM \
  --mortality-col vital_status \
  --followup-col followup_months \
  --output ./results/

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Implemented Clocks

Clock	Reference	Biomarkers	Key metric (NHANES)
PhenoAge	Levine et al. 2018 Aging Cell	9 blood	Pearson r=0.93, HR=1.83
KDM	Klemera & Doubal 2006 Mech Ageing Dev	8 blood	Pearson r=0.68, HR=1.41
DunedinPACEProxy	Proxy (NOT Belsky 2022)	7 blood	pace corr w/ PhenoAge accel r=0.84

Note: DunedinPACEProxy is a blood-biomarker approximation. The real DunedinPACE requires DNA methylation data (Illumina EPIC array).

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Features

• ✅ Unified interface — all clocks share the same transform() API
• ✅ Validated — PhenoAge implementation cross-validated against reference; zero numerical difference on N=4,086 NHANES participants
• ✅ Mortality benchmarking — Cox PH hazard ratios, Kaplan-Meier curves
• ✅ Bundled data — NHANES 1999-2000 with 20-year mortality follow-up, ready to use
• ✅ Interactive reports — Plotly HTML with comparison plots and benchmark table
• ✅ CLI tool — agingclockbench benchmark works out of the box
• ✅ 89% test coverage — 76+ tests, CI/CD on every push

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Documentation

Resource	Link
Full docs	aadityageddam-ux.github.io/aging_clock_bench
Quickstart	docs/quickstart
PhenoAge algorithm	docs/algorithms/phenoage
FAQ	docs/faq
Example notebooks	examples/

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Citation

If you use AgingClockBench in your research, please cite:

@software{geddam2026agingclockbench,
  author = {Geddam, Aaditya},
  title  = {AgingClockBench: Benchmarking biological aging clocks},
  url    = {https://github.com/aadityageddam-ux/aging_clock_bench},
  year   = {2026}
}

Also cite the underlying clock papers:

• Levine ME, et al. Aging Cell. 2018. (PhenoAge)
• Klemera P, Doubal S. Mech Ageing Dev. 2006. (KDM)

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Contributing

Contributions welcome! See CONTRIBUTING.md.

To add a new clock, implement the BaseClock interface — see the FAQ.

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License

MIT © Aaditya Geddam