AION — Algebraic Interval Ontology for Clinical Networks

Formal model for clinical information systems. Foundation Module FM-3. Dual-licensed: EUPL-1.2 / Commercial.

Repository Status

This Codeberg repository contains the initial concept commit of AION from April 2026, comprising the foundation module (FM-3), the Contributor License Agreement, the dual-license declaration, and the file-header template.

The active software development has continued elsewhere. The current release is published on PyPI; this repository serves as a historical anchor for the original concept and the dual-licensing setup.

Current Software — install from PyPI

The actively maintained software is published on PyPI:

pip install aion-clinical

• PyPI: https://pypi.org/project/aion-clinical/
• Latest release: 1.10.1 (May 2026)
• License badge: EUPL-1.2

The PyPI distribution includes:

• Type hierarchy and Allen interval algebra
• Temporal Conditional Frequency Graphs (TCFG) for pattern mining
• FHIR R4 import/export
• HL7 v2 file import
• HL7 v2 MLLP live listener (real-time)
• Pluggable authentication (API-Key, LDAP/AD, OIDC)
• Append-only audit trail
• SQLite storage (PostgreSQL backend planned)
• Optional GUI (PySide6) and Jupyter integration
• Optional causal inference via DoWhy

For a complete release history and the full changelog, see the PyPI project page or the package's own CHANGELOG.md.

Theoretical Foundation

The mathematical foundation of AION — type hierarchy semantics, Allen-algebra interval relations, TCFG semantics, and the causal inference framework — is documented as a separate scholarly artifact and archived on Zenodo with its own DOI:

DOI: 10.5281/zenodo.19548857

Please cite the Zenodo record when referring to the theoretical model. The software itself currently does not have a separate software-DOI; when citing a specific software version, the canonical reference is the PyPI release identifier (e.g. aion-clinical 1.10.1).

Licensing

AION is offered under a dual license:

• EUPL-1.2 (European Union Public Licence v1.2) for open-source use. Full text: see LICENSE in the PyPI distribution and at https://joinup.ec.europa.eu/collection/eupl/
• Commercial license available for proprietary integration, redistribution under non-EUPL terms, or settings where EUPL obligations are not desired.

For commercial licensing inquiries, please contact:

ISCaD GmbH 30900 Wedemark, Germany licensing@iscad-it.de

The Contributor License Agreement (CLA.md) and the commercial license terms (LICENSE-COMMERCIAL.md) in this repository document the dual-licensing setup as established at project initiation.

Disclaimer

AION Clinical is not a certified medical device under the EU Medical Device Regulation (MDR 2017/745). It is provided as a research and informatics tool. Use in patient care requires appropriate clinical governance, validation, and — where applicable — separate regulatory certification.

See the NOTICE file for the full disclaimer.

Contact

Repository maintained by Friedhelm Matten / ISCaD GmbH. Last updated: May 2026.