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This release is a pre-release and may not be stable for production use.

ARIELSpatial

ARIEL is a library for spatial multiomic integration with modular encoders, graph backbones, multimodal aggregators, probabilistic decoders, loss composition, clustering, profiling, and reproducible seeding.

What this release contains

Version 0.1.0 ships the data-preparation and seeding layers:

  • ARIELSpatial.preprocessing: RNA preprocessing with Seurat SCTransform and PCA, ADT CLR normalization and PCA, in-tissue spot filtering with spatial coordinates, and barcode and sparse-matrix utilities.
  • ARIELSpatial.seed: process-wide seeding and namespaced Python, NumPy, and PyTorch random generators, including DataLoader worker seeding.

Installation

Releases are currently alpha pre-releases, so pip needs --pre:

pip install --pre arielspatial

The package is imported as ARIELSpatial:

import ARIELSpatial

Requirements

  • Python 3.10 or newer on Linux.

  • An R installation with the Seurat, SeuratObject, sctransform, Matrix, dplyr, and SingleCellExperiment packages. RNA preprocessing runs Seurat SCTransform through rpy2 and anndata2ri.

  • Optional GPU acceleration: an NVIDIA GPU with a CUDA 13 runtime and the gpu extra, which installs cupy-cuda13x and rapids-singlecell-cu13:

    pip install --pre "arielspatial[gpu]"
    

License

MIT. See LICENSE.

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