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Utility package to find gene <-> drug relationships within CARD

Project description

# Card trick
A software package that extracts confers_resistance_to_drug relationships from
The Comprehensive Antibiotic Resistance Database (CARD)


## Installation
This package requires Python3
pip3 install card-trick

## Usage
usage: card-trick [-h] [-v] {update,search} ...

positional arguments:
{update,search} The following commands are available. Type contig_tools
<COMMAND> -h for more help on a specific commands
update Get latest CARD ontology
search search CARD ontology

optional arguments:
-h, --help show this help message and exit
-v, --version display the version number

### Update ontology database
The software comes preloaded with version 3.0.0 of the database (October 2018 release).
The update command `card-trick update` will download the latest version of the database and store it in your
home directory in the .card-trick directory

### Search ontology database
This will return matches to the STDOUT in either tsv (default) or json format. To write to a file just append `> OUTPUT_FILE` to the command

Specify a full or partial gene name with the -g argument to search for antibiotics resistance to which is conferred by the specified gene e.g
card-trick search -g ctx
This will return the following output
gene antibiotics
CTX-M-3 cefalotin,ceftazidime,ceftriaxone
CTX-M-15 ceftazidime
CTX-M-27 cefalotin,ceftazidime
CTX-M-55 ceftazidime,ceftriaxone

Specify a full or partial antibiotic name with the -a argument to search for genes who confer resistance to the specified antibiotic
card-trick search -a tigecycline
This will return the following output
antibiotic genes
tigecycline AcrAB-TolC,AdeABC,mepA,oqxAB,tet(A),tetX

## Using in a python script or program
import card_trick
genes_conferring_resistance = card_trick.ontology_functions.search_antibiotics('tigecycline')
antibiotics = card_trick.ontology_functions.search_genes('ctx-m-15')

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