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CLIO — an AI workspace for scientific data

Website & downloads · User guide · Latest release

CLIO is an AI workspace for scientific data, part of IOWarp. Work with files, analysis, visualizations and documents in Desktop or your browser. Connect a local model, a provider account, or a model service from your lab.

  • Organize work in workspaces and conversations, with persistent ARC memory.
  • Extend CLIO with marketplace plugins, agents, tools and flows.
  • Inspect HDF5, Parquet and CSV data through MCP tools.
  • Run tools where your data lives, locally or on a remote computer.

Get CLIO

Start at clio.iowarp.ai for the Desktop installer for Windows, Apple Silicon macOS, or Linux. Choose a bundled installer: it includes the CLIO service and its runtimes. Setup prepares the tools and Office renderer; then open CLIO Desktop and choose a model.

You can also install Desktop from a terminal:

Linux / macOS

curl -fsSL https://clio.iowarp.ai/desktop.sh | bash

Windows (PowerShell)

irm https://clio.iowarp.ai/desktop.ps1 | iex

See the installation guide for supported systems, selecting a release, remote deployment and first-launch steps. An assistant such as Claude Code can follow the installation instructions for AI assistants.

Web and servers

For a browser deployment, use the published Web image. From a clone of this repository:

docker compose up clio-web
# Open http://localhost:8080

For a local service with Web, run the install script without --desktop (-Desktop on Windows), then run clio or clio web. Use clio start for a headless service, and clio status, clio stop and clio logs to manage it. The script provisions Python and uv; a release install needs no Git or Go.

The legacy TUI is frozen and unsupported as of 0.9.5.1. It is not a valid way to install, run or verify current CLIO. New releases do not ship its binaries or Docker image; clio attach reports this status instead of running an old binary. Its source and integration notes remain for a future upgrade.

Contributors and backend-only installations

--source installs main; --dev --source installs develop; add --ref <ref> to select a branch, tag or commit. On Windows use -Source, -Dev and -Ref. Source mode needs Git and installs the service without building a frontend. See contributor setup for Web/Desktop development.

CLIO 0.9.5.1 uses standard Python 3.14 with the GIL enabled. For a persistent backend-only installation with the verified SDK roots:

uv tool install --python 3.14 --with dspy==3.4.0 --with fastmcp==4.1.2 --with fastmcp-tasks==4.1.2 --with mcp==2.2.0 clio-agent==0.9.5.1
clio-agent serve

Reserve uvx / uv tool run for disposable checks. The installer reference covers paths, version selection, lifecycle commands and uninstalling.

Documentation and contributing

Use the website documentation for installation, models, workspaces, plugins and examples. Repository references:

License and citation

BSD-3-Clause.

@software{clioagent2026,
  title  = {CLIO Agent: Autonomous Agent for Scientific Data Management},
  author = {IOWarp Team},
  year   = {2026},
  url    = {https://github.com/iowarp/clio-agent},
}

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