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Equiconc is an equilibrium concentration solver for monomer/complex systems (like networks of interactions of DNA/RNA strands), when the complexes are already enumerated and standard free energies of binding are known. It implements the convex optimization method of Dirks et al. (2007), without any other portions of the paper; as such, it can be applied generally, for example, to find equilibrium concentrations in tile assembly systems.

The library is written in Rust, with a Python interface that is intended to be easily usable.

There is also an in-browser web interface, which runs the solver in your browser directly (not a server). This interface was inspired by COFFEE; Equiconc also supports a modified version of their log-based optimization (Yu et al, 2025).

Quick example

import equiconc

# A + B <=> AB with DG = -10 kcal/mol at 25 C (default)
eq = (
    equiconc.System()
    .monomer("A", 100e-9)       # 100 nM
    .monomer("B", 100e-9)
    .complex("AB", [("A", 1), ("B", 1)], dg_st=-10.0)
    .equilibrium()
)

print(f"Free [A] = {eq['A']:.2e} M")
print(f"Free [B] = {eq['B']:.2e} M")
print(f"[AB]     = {eq['AB']:.2e} M")

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Credits

Author: Constantine Evans

GitHub Statistics

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BSD-3-Clause
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Python >=3.10

Tags

equilibrium nucleic-acid thermodynamics DNA RNA

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Credits

Author: Constantine Evans

GitHub Statistics

Data verified by PyPI on Apr 25, 2026
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Release files for equiconc 0.4.1

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Source distribution for equiconc 0.4.1
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equiconc-0.4.1-cp314-cp314t-win_amd64.whl 217.7 kB CPython 3.14 CPython 3.14 free-threading Windows x86-64 Details
equiconc-0.4.1-cp314-cp314t-manylinux_2_17_x86_64.manylinux2014_x86_64.whl 365.7 kB CPython 3.14 CPython 3.14 free-threading Linux glibc 2.17+ x86-64 Details
equiconc-0.4.1-cp314-cp314t-macosx_11_0_arm64.whl 320.2 kB CPython 3.14 CPython 3.14 free-threading macOS 11.0+ ARM64 Details
equiconc-0.4.1-cp314-cp314t-macosx_10_12_x86_64.whl 329.9 kB CPython 3.14 CPython 3.14 free-threading macOS 10.12+ x86-64 Details
equiconc-0.4.1-cp313-cp313t-win_amd64.whl 218.4 kB CPython 3.13 CPython 3.13 free-threading Windows x86-64 Details
equiconc-0.4.1-cp313-cp313t-manylinux_2_17_x86_64.manylinux2014_x86_64.whl 365.8 kB CPython 3.13 CPython 3.13 free-threading Linux glibc 2.17+ x86-64 Details
equiconc-0.4.1-cp313-cp313t-macosx_11_0_arm64.whl 320.1 kB CPython 3.13 CPython 3.13 free-threading macOS 11.0+ ARM64 Details
equiconc-0.4.1-cp313-cp313t-macosx_10_12_x86_64.whl 330.0 kB CPython 3.13 CPython 3.13 free-threading macOS 10.12+ x86-64 Details
equiconc-0.4.1-cp310-abi3-win_amd64.whl 225.2 kB CPython 3.10 abi3 Windows x86-64 Details
equiconc-0.4.1-cp310-abi3-manylinux_2_17_x86_64.manylinux2014_x86_64.whl 372.6 kB CPython 3.10 abi3 Linux glibc 2.17+ x86-64 Details
equiconc-0.4.1-cp310-abi3-macosx_11_0_arm64.whl 327.5 kB CPython 3.10 abi3 macOS 11.0+ ARM64 Details
equiconc-0.4.1-cp310-abi3-macosx_10_12_x86_64.whl 336.7 kB CPython 3.10 abi3 macOS 10.12+ x86-64 Details

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