gnomancer

Your DNA, decoded on your own machine.
gnomancer.com · get your raw data · install · PyPI · MCP Registry · Discord

Take the raw file you already downloaded from AncestryDNA, 23andMe, MyHeritage, FamilyTreeDNA or LivingDNA and turn it into one readable report. Everything runs on your computer. Nothing is uploaded.

Quick start

pipx install gnomancer      # Python 3.10+; Java 11+ for the haplogroup and PharmCAT steps
gnomancer setup             # fetches the open-source tools and reference files once (~250 MB)
gnomancer ~/Downloads/AncestryDNA.zip

Open AncestryDNA_analysis/REPORT.html. macOS: brew install codebase/tap/gnomancer pulls Python and Java for you. No Python at all? curl -fsSL https://gnomancer.com/install.sh | bash. Windows: via WSL.

What you get

• Plain language first. An at-a-glance digest, then a narrative your own AI assistant can write from a prompt the run gives you.
• Lineages. Y haplogroup (yhaplo, plus Yleaf on current YFull/FTDNA/ISOGG trees) and mtDNA haplogroup (Haplogrep3), each with population context.
• Traits and ancestry markers. About 110 well-replicated sites: pigmentation, lactose, caffeine, bitter taste, blood group and more.
• Health, carefully. Carrier sites, common risk variants, a ClinVar scan of every typed site with plausibility scoring, and PharmCAT pharmacogenomics. All collapsed by default so nobody sees a result they didn't ask for.
• Stays current. gnomancer watch re-checks ClinVar each month and tells you only what was reclassified at sites you carry.
• Honest limits. Every section says what the chip can and cannot tell you.

Use it from your AI assistant

gnomancer is also an MCP server. Connect it and ask "what does my report say about caffeine?"

claude mcp add gnomancer -- uvx gnomancer serve          # Claude Code; Claude Desktop/Cursor: command "uvx", args ["gnomancer","serve"]

Only derived results reach the assistant, never the raw file. The first analyze downloads the tools automatically. Health tables are separate tools fetched only on request. The repo also works as a Claude plugin (skills/gnomancer/SKILL.md).

Privacy

Your genotype file never leaves your machine. The only network traffic is the one-time download of public tools and references. The optional --ai flag sends the structured results (not the file) to the Anthropic API to write the narrative, and only when you ask.

Not medical advice

A genotyping array reads about 0.02% of the genome at pre-chosen sites, and its calls at rare sites are wrong often enough that a clinical lab found 40% did not confirm. gnomancer tells you what the chip says and how far to trust it. Confirm anything that matters with a clinical-grade test and a clinician or genetic counselor.

More

Discord community · CLI options · vendors and quirks · the marker panel · tools under the hood · development · MCP registry · contributing

MIT licensed. The bundled tools keep their own licenses.

_{mcp-name: com.gnomancer/gnomancer}