ICg-CaST

ICg-CaST is a research package for synthetic integrated carcinogenomics experiments: causal-state simulation, mechanism-bottleneck models, and ICg-Bench benchmark variants with known data-generating processes.

The distribution name is icg-cast, the Python import is icg_cast, and the command-line entry point is icg-cast.

Current Status

This repository is in an early cleanup and migration stage. The new package currently focuses on:

• Mechanism-Bottleneck Causal Networks in src/icg_cast/bottleneck.py.
• Time-to-event/RMST helpers in src/icg_cast/survival.py.
• Coefficient registry and seedable coefficient-prior uncertainty in src/icg_cast/coefficients/.
• ICg-Bench DGP variants, task scoring, and leaderboard helpers in src/icg_cast/benchmark/.

The starter kit has been migrated into the active package under src/icg_cast. Active docs, tests, and demos use that package layout.

Install

python -m pip install -e ".[dev]"

Quickstart

Generate a synthetic cohort:

icg-cast simulate --n 120 --months 12 --seed 7 --outdir outputs/demo

Generate a cohort under one coefficient-prior draw:

icg-cast simulate \
  --n 120 \
  --months 12 \
  --seed 7 \
  --coefficient-mode prior_sample \
  --coefficient-seed 42 \
  --outdir outputs/demo_uncertainty

Run the full reproducible package demo in one command:

icg-cast make-demo --n 120 --months 72 --seed 7 --outdir outputs/demo

Train baseline models:

icg-cast train \
  --cohort outputs/demo/synthetic_icg_cohort.csv \
  --outdir outputs/demo \
  --seed 7

Evaluate the saved model bundle:

icg-cast evaluate \
  --cohort outputs/demo/synthetic_icg_cohort.csv \
  --model outputs/demo/model_bundle.joblib \
  --outdir outputs/demo

Export the theory graph:

icg-cast graph --outdir outputs/demo

Use the Python API:

from icg_cast import SimConfig, simulate_cohort, train_baselines

cohort, trajectories = simulate_cohort(SimConfig(n=120, months=72, seed=7))
metrics, importance, counterfactual, bundle = train_baselines(cohort, seed=7)

List registered benchmark variants:

icg-cast bench list

Inspect a variant:

icg-cast bench info misspecified_signs

Run one small benchmark experiment:

icg-cast bench run \
  --cohort linear_lowhet \
  --variant sign_constrained_augmented \
  --seed 7 \
  --n 400 \
  --months 36

Run the local browser app:

python -m pip install -e ".[app]"
streamlit run streamlit_app.py

For requirements.txt based Streamlit deployments, install with python -m pip install -r requirements.txt.

The Streamlit app writes results under outputs/streamlit/<run-name> and wraps simulation, demo, training/evaluation, graph export, and benchmark workflows.

Documentation and Materials

Project documentation starts at docs/index.md. Field and intervention dictionaries live under materials/:

Build the documentation locally:

python -m pip install -e ".[docs]"
make docs

• materials/data_dictionary.csv
• materials/intervention_dictionary.csv
• materials/provenance_template.json

Optional real-data adapters live under icg_cast.data_sources. They accept local files only and record provenance; they do not download public datasets.

Citation and License

Citation metadata is in CITATION.cff. The package metadata and LICENSE file declare Apache-2.0 for the source code unless a maintainer changes that before release.

Scope and Limitations

This is a synthetic theory-development and benchmarking scaffold. It is not a clinical diagnostic, individual-risk model, chemical safety classifier, medical device, or substitute for experimental toxicology, epidemiology, or regulatory review.

Synthetic benchmark performance does not imply real-world biological validity. Real-data adapters, if added, must remain optional and provenance-tracked.