Simulation of an electrophysiological A549 cancer cell model using individual ion channels across the membrane

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Electrophysiological Cancer Cell Model

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Attempt to model an A549 cancer cell's ion channels using an HMM (Hidden Markov Model) and simulation of voltage + current development accross the membrane of the cell.

This software comes in three flavours:

  • to run the main.rs simulation, do cargo run,
  • to compile the Python module, do maturin develop --features pyo3,
  • to precompile for the Astro dashboard, do bun run wasm-pack build frontend.

A visual to capture your interest:

Ion Channels (Image source: here).

This computational model is based on Langthaler et al., 2021: A549 in-silico 1.0: A first computational model to simulate cell cycle dependent ion current modulation in the human lung adenocarcinoma.

The Simulation Dashboard

Screenshot of the User Interface

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0.2.5

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0.2.4

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