mAbLab 1.0.5

A library for analyzing monoclonal antibody characteristics by domain.

mAbLab

mAbLab is a Python library for analyzing monoclonal antibody (mAb) characteristics with domain granularity.

Features

• Analyze VL, VC, VH, CH1, CH2, CH3, Fab, LC, HC, Fc, andHinge domains of antibodies.
• Calculate protein properties such as molecular weight, isoelectric point, and extinction coefficients.
• Annotate CDR regions and infer germline genes.
• number sequences with Kabat, Martin, IMGT numbering schemes

Installation

Install the library using pip:

pip install mAbLab

Usage

import mAbLab

# Example sequences
hc_sequence = "EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHW..."
lc_sequence = "DIQMTQSPSSLSASVGDRVTITCRASQGIRNYLAW..."

# Create a Mab object
mab = mAbLab.Mab(hc1_aa_sequence=hc_sequence, lc1_aa_sequence=lc_sequence)

# Access Fab properties
print(mab.fab1.properties.charge_at_ph(6))

License

This project is licensed under the MIT License. See the LICENSE file for details.