mAbLab
mAbLab is a Python library for analyzing monoclonal antibody (mAb) characteristics with domain granularity.
Features
- Analyze VL, VC, VH, CH1, CH2, CH3, Fab, LC, HC, Fc, andHinge domains of antibodies.
- Calculate protein properties such as molecular weight, isoelectric point, and extinction coefficients.
- Annotate CDR regions and infer germline genes.
- number sequences with Kabat, Martin, IMGT numbering schemes
Installation
Install the library using pip:
pip install mAbLab
Usage
import mAbLab
# Example sequences
hc_sequence = "EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHW..."
lc_sequence = "DIQMTQSPSSLSASVGDRVTITCRASQGIRNYLAW..."
# Create a Mab object
mab = mAbLab.Mab(hc1_aa_sequence=hc_sequence, lc1_aa_sequence=lc_sequence)
# Access Fab properties
print(mab.fab1.properties.charge_at_ph(6))
License
This project is licensed under the MIT License. See the LICENSE file for details.
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