Pepkio Mendelian Cross Solver

Call the Pepkio mendelian-cross-solver REST API from Python to generate Punnett squares, offspring ratios, and step-by-step walkthroughs for Mendelian and non-Mendelian crosses.

What It Does

Genetics teaching and homework verification need Punnett grids for complete dominance, incomplete dominance, codominance, ABO blood types, and X-linked traits—each with different notation and ratio rules. Rebuilding gamete tables and phenotype mapping in a notebook for every cross is tedious and easy to get wrong.

This package submits parent genotypes and a dominance_mode to the same Pepkio Tools engine as the hosted Mendelian Cross Solver web calculator. It returns filled grids, genotype and phenotype ratios, walkthrough steps, warnings, and shareable run permalinks.

Programmatic runs require a network connection and a Pepkio API key. Calculations are not bundled for offline use.

Features

• Five dominance modes: complete, incomplete, codominant, multiple_alleles (ABO only in MVP), sex_linked
• Custom phenotype labels; ABO allele hierarchy; sex-linked recessive or dominant trait labeling
• Manifest examples: complete_monohybrid, incomplete_snapdragon, abo_cross, sex_linked_hemophilia, codominant_roan, dihybrid_pea, sex_linked_dominant
• CLI: pepkio-mendelian-cross-solver manifest and run
• Configuration via PEPKIO_API_KEY, LOCAL_PEPKIO_API_KEY, and PEPKIO_API_BASE_URL

Installation

pip install pepkio-mendelian-cross-solver

Set an API key with tools:run scope before calling run():

export PEPKIO_API_KEY="your-key"

Create a key in your Pepkio account API keys settings.

Quick Example

from pepkio_mendelian_cross_solver import PepkioClient

with PepkioClient() as client:
    inp = client.get_example_input("abo_cross")
    result = client.run(inp)
    print(result.permalink)
    print("phenotype ratio:", result.result["phenotype_ratios"]["ratio"])

CLI:

pepkio-mendelian-cross-solver run --example complete_monohybrid

Manifest inspection does not require an API key.

Typical Use Cases

• Verify monohybrid Aa × Aa (3:1) and dihybrid AaBb × AaBb (9:3:3:1) ratios
• Model ABO blood type crosses (I^A i × I^B i)
• Set up X-linked recessive or dominant Punnett squares with standard notation
• Incomplete dominance (snapdragon) and codominance (roan cattle) homework checks
• Automated genetics problem sets in notebooks or CI

Scientific Background

Monohybrid crosses under complete dominance yield a 3:1 phenotype ratio (Aa × Aa). Incomplete dominance and codominance both give 1:2:1 phenotype ratios when heterozygotes differ from homozygotes. ABO crosses use multiple alleles with I^A, I^B, and i. Sex-linked traits use X-chromosome notation with Parent 1 female and Parent 2 male.

Web Application

For researchers who prefer a graphical interface, an interactive Mendelian Cross Solver is available in the browser.

The web interface adds a live grid, 28 curated textbook presets, collapsible walkthroughs, PNG/SVG export, copy-grid-as-table, shareable permalinks, and print-friendly display.

Documentation and Resources

Source code and issue tracking: github.com/pepkio/pepkio-mendelian-cross-solver

Web calculator: pepkio.com/tools/mendelian-cross-solver

About Pepkio

Pepkio develops software tools and provides bioinformatics analysis services for life science research. See pepkio.com for additional calculators and analysis services.

Keywords

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