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PhaSePred

Predict the phase-separation propensity of a protein from its amino-acid sequence. Implementation of Chen et al. 2022 PNAS.

Install

pip install phasepred

Requires Python >= 3.12.

Use

phasepred predict --fasta proteins.fasta --mode SaPS --output scores.csv

Four modes: SaPS and PdPS (any species, 8 features), hSaPS and hPdPS (human, 10 features). The output CSV carries the score plus every feature value.

Input can also be UniProt accessions:

phasepred predict --ids "P35637,Q9Y2W1" --mode SaPS --output scores.csv

Feature tools

Five of the nine feature components ship with the package and work immediately. The rest need a one-time install:

phasepred check-tools

This prints a status row per component, and for every missing one the exact command that installs it.

More

Source, training data, retraining and AUC validation against the paper: https://github.com/notwhiteblank/PhaSePred

Metadata

Release files for phasepred 1.0.0

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