pkmodel-zxara
A Python package for pharmacokinetics modelling of drug delivery systems.
Read the Docs here.
Installation
Use the package manager pip to install.
pip install pkmodel-zxara
Usage
Navigate to the model directory.
cd lib/python3.8/site-packages/pkmodel_zxara/
Run the main.py file.
python3 -m __main__.py
Theory
Pharmacokinetics (PK) provides a quantitative basis for describing the delivery of a drug to a patient, the diffusion of that drug through the plasma/body tissue, and the subsequent clearance of the drug from the patient’s system. PK is used to ensure that there is sufficient concentration of the drug to maintain the required efficacy of the drug, while ensuring that the concentration levels remain below the toxic threshold. For an introductory theory, we recommend "Principles of Pharmacokinetics", by Ratain et. al. Available from: https://www.ncbi.nlm.nih.gov/books/NBK12815/
The model presented discretises the body into several linked, homogeneous compartments through which the concentration of an administered drug is tracked. It allows the user to specify the drug administration protocol, as well as physiological parameters.
Demo
The program outputs a figure and the associated data. With these users may compare models with different protocols and physiological parameters. An example is provided in the results directory, as shown in the following figure.
Contributing
Pull requests are welcome. For major changes, please open an issue first to discuss what you would like to change.
Please make sure to update tests as appropriate.
License
1 maintainer
Release files for pkmodel-zxara 1.3.0
For a detailed explanation of source distributions (sdists) and built distributions (wheels), please see the package formats documentation.
Source distribution (sdist)
| File | Size | Uploaded | |
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| pkmodel_zxara-1.3.0.tar.gz | 11.2 kB | Details |
Built distribution (wheel)
| File | Interpreter | ABI | Platform | Reset |
|---|---|---|---|---|
| pkmodel_zxara-1.3.0-py3-none-any.whl | Python 3 | none | any | Details |
Total release size: 23.3 kB
Release files / pkmodel_zxara-1.3.0.tar.gz
| Download URL | pkmodel_zxara-1.3.0.tar.gz |
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| Size | 11.2 kB |
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Release files / pkmodel_zxara-1.3.0-py3-none-any.whl
| Download URL | pkmodel_zxara-1.3.0-py3-none-any.whl |
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