Population-level Complex Phenotypic Intercellular signaling Linkage Analyzer
Project description
a multimodal computational framework designed to decompose phenotype-associated intercellular signaling. Guided by diverse phenotypes, PopCILA identifies phenotype-associated signaling at population scale—beginning with ligand–receptor interactions and extendable to downstream transcriptional cascades—and then projects these signals onto single-cell or spatial data to pinpoint specific cellular actors and tissue niches and to resolve intercellular signaling events that underlie phenotypic variation.
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