Skip to main content
Help us improve PyPI by participating in user testing. All experience levels needed!

An application to quantify and annotate miRNA expression.

Project description

microRNAs (miRNAs) are an important class of small noncoding RNAs (~22nt) with multiple and widespread regulatory roles in many development and disease processes. We have created the tool Prost! to explore metazoan miRNA-enriched RNA-Seq data. Prost! quantifies and normalizes expression levels (in the form of Illumina reads) in several views that are suitable as input into differential expression software such as DESeq2. Some key features of Prost! include the identification of both candidate mirror-miRNAs and putative 5 ́/3 ́ mature miRNA arm switching. Of particular interest is the tightly regulated post-transcriptional modification of miRNAs via multiple modes of regulation during their biogenesis. Such modifications have been found to have important consequences on characteristics such as Argonaute loading, target choice, and miRNA turnover. Prost! provides valuable quantification across samples of several classes of miRNA modifications, for example putative seed shifting, seed editing, and untemplated 3 ́ nucleotide additions.

Project details


Release history Release notifications

This version
History Node

0.7.46

History Node

0.7.45

History Node

0.7.44

History Node

0.7.43

History Node

0.7.42

History Node

0.7.41

History Node

0.7.36

History Node

0.7.35

History Node

0.7.34

History Node

0.7.33

History Node

0.7.31

History Node

0.7.30

History Node

0.7.29

History Node

0.7.28

History Node

0.7.27

History Node

0.7.25

History Node

0.7.24

History Node

0.7.23

History Node

0.7.6

History Node

0.7.5a2

Download files

Download the file for your platform. If you're not sure which to choose, learn more about installing packages.

Filename, size & hash SHA256 hash help File type Python version Upload date
prost-0.7.46.tar.gz (121.6 kB) Copy SHA256 hash SHA256 Source None Mar 26, 2018

Supported by

Elastic Elastic Search Pingdom Pingdom Monitoring Google Google BigQuery Sentry Sentry Error logging CloudAMQP CloudAMQP RabbitMQ AWS AWS Cloud computing Fastly Fastly CDN DigiCert DigiCert EV certificate StatusPage StatusPage Status page