proteinpy 0.1.2

A Python toolkit for fetching and analyzing protein sequences.

ProteinPy

A Python toolkit for fetching and analyzing protein sequences.

Features

• Sequence Retrieval
  Retrieve protein sequences directly from the UniProt Knowledgebase via accession IDs.

• Biochemical Property Analysis
  Calculate key biochemical properties such as:

  • Molecular weight
  • Isoelectric point (pI)
  • GRAVY (Grand Average of Hydropathicity)
  • Aromaticity
  • Aliphatic index

• Sequence Manipulation

  • Extract sub-sequences and generate sliding k-mers
  • Perform amino acid mutations (single or batch)
  • Identify sequence motifs using custom regular expressions

• Data Export
  Export sequences in FASTA format and analytical results in JSON or CSV.

• Visualization
  Create amino acid composition and distribution plots using Matplotlib.

• Reporting
  Generate clear, user-friendly summary reports for quick interpretation.

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Installation

pip install proteinpy

Example Usage

from proteinpy import Protein

# Initialize a protein object with a UniProt accession
p = Protein("P69905")  # Hemoglobin alpha subunit

# Fetch and print summary statistics
p.summary()

# Get amino acid counts and visualize them
p.aa_counts()
p.aa_distribution()

# Simulate a mutation at position 42
mutated_seq = p.mutate(42, "K")

# Find a motif using regex
positions = p.find_motif("N[^P][ST][^P]")

# Export as JSON or CSV
p.to_json()
p.to_csv("P69905.csv")