PyReconstruct

PyReconstruct is an actively maintained, extensible version of Reconstruct written in Python in the lab of Kristen Harris at the University of Texas at Austin. Please check out our paper introducing PyReconstruct and feel free to send us a message if you have any questions:

• Michael Chirillo: michael.chirillo@uri.edu
• Dusten Hubbard: dusten@utexas.edu

Documentation

An installation guide, quickstart, and manuals can be found at our lab's wiki site hosted at UT Austin and at the PyReconstruct repo wiki. A quick launch guide follows below.

Then it would say lanch party, Kevin.

In a virtual environment running Python 3.11, install bleeding-edge PyReconstruct:

pip install git+https://github.com/synapseweb/pyreconstruct

or stable PyReconstruct:

pip install pyreconstruct

then launch PyReconstruct from the command line:

PyReconstruct

To install a dev version of PyReconstruct, see here.

Bug reports / Feature requests

If you notice a problem, would like to suggest a feature, or have ideas on improving our documentation, please submit an issue. We appreciate the help!

Citation

If you use PyReconstruct in published work, please cite our paper:

@article{Chirillo2025,
	title = {{PyReconstruct}: {A} fully open-source, collaborative successor to {Reconstruct}},
	author = {Chirillo, Michael A. and Falco, Julian N. and Musslewhite, Michael D. and Lindsey, Larry F. and Harris, Kristen M.},
	journal = {Proceedings of the National Academy of Sciences},
	volume = {122},
	number = {31},
	pages = {e2505822122},
	year = {2025},
	month = {July},
	doi = {10.1073/pnas.2505822122},
	url = {https://www.pnas.org/doi/10.1073/pnas.2505822122}
}

and this repo if you'd like:

@software{Falco2025,
    author = {Kristen Harris Lab},
    title = {PyReconstruct},
    version = {1.20.0},
    month = {June},
    year = {2026}
    url = {https://github.com/synapseweb/pyreconstruct},
}