reiberdiagram 1.0.3

Package for creating diagrams aiding CSF diagnostics

Reiberdiagram

Python module to create an image file for each measured immunoglobulin.

The Reiberdiagram was invented by Hansotto Reiber to visualize reasons for unusual high concentrations of proteins in the Cerebrospinal fluid (CSF).¹² This may be due to problems with the blood brain barrier or antibody synthesis in the CSF. The diagram consist of two main curves enclosing the normal range, some additional curves labelled 20%, 40% etc., an age-dependent vertical separation line and a mark that highlights the position of the current measurement. The x-axis is the albumin quotient and the y-axis the immunoglobulin quotient.

Images can be created for IgA, IgG and IgM

Usage:

You can either evaluate a csv file (see example in test folder) or a single patient. Example:

test_csv_file:
id;dob;alb_serum;alb_csf;iga_serum;iga_csf;igg_serum;igg_csf;igm_serum;igm_csf
001;2002-09-18;49.2;1.3;;;1090.1;22.3
002;1976-11-19;49.2;1.3;100.2;13.4;;;345.6;33.1

from reiberdiagram import create_images_for_file, ImageType
create_images_for_file(test_csv_file, out_file=test_file_path, image_type=ImageType.PNG)

from reiberschema import create_images, PatientData, ImageType
pat = PatientData(birth_date_iso="2022-09-13", albumin_serum=1000, albumin_csf=10, igg_serum=133.5, igg_csf=1.5)
create_images(data=pat, out_file="test", image_type=ImageType.PNG)

Example image:

1. Reiber H (1994). The hyperbolic function: a mathematical solution of the protein flux/CSF flow model for blood-CSF barrier function J Neurol Sci 126:243-245. ↩

2. Reiber H (1994). Flow rate of cerebrospinal fluid (CSF)- a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases. J Neurol Sci 122:189-203 ↩