risk-bridge 1.0.3

Risk Bridging through Constrained MLE

Risk Bridge

Risk Bridge is a Python package for estimating transportable binary-risk models when the available cohorts do not all contain the same information. It combines propensity-score sampling, reference-cohort calibration, maximum likelihood estimation, and constrained maximum likelihood estimation (cMLE) into reproducible simulation and user-data workflows.

Package title: Risk Bridging through Constrained MLE.

Motivation

Risk models often need to be evaluated or adapted across related populations: a target cohort, a source cohort, and a reference cohort. Standard model fitting can drift when covariate distributions, calibration strata, or observed risk markers differ across those cohorts. Risk Bridge provides a repeatable way to compare ordinary ML estimates with calibration-constrained estimates while preserving diagnostics, thresholds, and run metadata.

Foundation Papers

• Cao, Y., Ma, W., Zhao, G., McCarthy, A. M., & Chen, J. (2024). A constrained maximum likelihood approach to developing well-calibrated models for predicting binary outcomes. Lifetime Data Analysis, 30(3), 624-648.

• Wang, Le., Chen, J. (2026). Developing Accurate Risk Prediction Using Biased Electronic Health Record Data. Manuscript in preparation.

Key features

• Simulated Scenario 1-3 workflows for reproducible method evaluation.
• User-data workflow for prepared target, source, and reference CSV datasets.
• Propensity-score matched and random-sampled source paths.
• Constrained MLE solver ladder with calibration-violation diagnostics.
• CSV-first output contract with optional parquet mirrors.
• Public Python API and risk-bridge command-line interface.
• Unit tests covering preprocessing, calibration, likelihoods, constraints, optimization, metrics, sampling, and pipeline behavior.

Installation

From the package index (standard path)

uv add risk-bridge
# or: pip install risk-bridge

From a repository checkout

Risk Bridge is also packaged with uv and a checked-in lock file. To install uv, read this.

git clone [e-mail]/SaehwanPark/risk-bridge.git
cd risk-bridge
uv sync --locked

Run the test suite:

uv run pytest
uv run basedpyright

The orchestration layer uses comp-builders for explicit Result composition in recoverable validation paths. uv sync --locked installs it from the package index as recorded in uv.lock.

Quick start

Run a small simulated scenario:

uv run risk-bridge \
  --mode simulated \
  --scenario 2 \
  --nsim 5 \
  --n-target 5000 \
  --n-source 2000 \
  --n-reference 5000 \
  --sample-size 500 \
  --output-root data \
  --run-label quickstart

Run on prepared CSV datasets:

uv run risk-bridge \
  --mode user-data \
  --target-csv /path/to/target.csv \
  --source-csv /path/to/source.csv \
  --reference-csv /path/to/reference.csv \
  --y-col label \
  --z-origin-col z_cont \
  --z-cat-col z_cat \
  --x-cols X1,X2,X3,X4 \
  --sample-size 500 \
  --nsim 1 \
  --output-root data \
  --run-label user_data

For a five-minute setup path, see QUICKSTART.md.

Architecture

Input cohorts
  target, source, reference
        ⬇️
Preprocessing and schema validation
        ⬇️
Calibration artifacts from reference cohort
  risk strata, external prevalence, X-support
        ⬇️
Sampling paths
  propensity-score matched source + random source
        ⬇️
Model fitting
  ML baseline + cMLE with calibration constraints
        ⬇️
Evaluation and exports
  estimates, ROC metrics, accuracy metrics, diagnostics, metadata

The public CLI delegates to typed configuration objects in risk_bridge.config, orchestration in risk_bridge.runs, reusable pipeline helpers in risk_bridge.pipeline, and numerical components in risk_bridge.likelihood, risk_bridge.constraints, risk_bridge.optimize, and risk_bridge.metrics.

Library usage

from risk_bridge import UserDataRunConfig, UserDataSchema, run_user_data

run_dir = run_user_data(
  UserDataRunConfig(
    target_df=target_df,
    source_df=source_df,
    reference_df=reference_df,
    schema=UserDataSchema(
      x_cols=("X1", "X2", "X3", "X4"),
      y_col="label",
      z_origin_col="z_cont",
    ),
    sample_size=500,
    output_root="data",
    run_label="hospital_a",
  )
)
print(run_dir)

Outputs

Each run writes a timestamped directory under output_root with intermediate/ and final/ folders. Start with these final outputs:

• final/run_metadata.csv (includes schema_version, currently 1.1.0)
• final/fit_diagnostics.csv
• final/est_cml_psm.csv
• final/calibration_metrics.csv
• final/calibration_residuals.csv
• final/roc_metrics.csv
• final/accuracy_metrics.csv

Reproduction

End-to-end regeneration commands for Scenario 2, numerical validation, external calibration validation, the synthetic transport second example, and the runtime/support-scaling protocol are in REPRODUCTION.md. Cite this software with CITATION.cff (Zenodo version DOI 10.5281/zenodo.21418590, concept DOI 10.5281/zenodo.21401396).

Repository layout

src/risk_bridge/  Python package source
tests/            Unit tests
cases/            Privacy-safe replication harnesses
examples/         Minimal runnable examples
docs/             Supplementary documentation
assets/           README visual assets

Documentation

• Quickstart
• Reproduction runbook
• Contributing
• User guide
• API reference
• Architecture overview
• Pipeline architecture
• Solver strategy
• Replication cases
• Changelog
• Citation
• License

License

Risk Bridge is released under the Apache License 2.0.