rpg-conv 0.1.0

Robust protein marker to gene symbol resolution backed by SQLite.

robust-protein-gene

robust-protein-gene resolves protein marker aliases (for example ki--67, SMA, CD57) to canonical gene symbols using a local SQLite database.

Install

pip install robust-protein-gene

For development:

pip install -e ".[dev]"

Quick Start

from robust_protein_gene import GeneResolver

resolver = GeneResolver()  # creates/loads a local SQLite DB in ~/.robust_protein_gene

print(resolver.resolve_one("ki--67"))  # MKI67
print(resolver.resolve_one("ki67"))    # MKI67
print(resolver.resolve_one("SMA"))     # ACTA2
print(resolver.resolve_one("CD57"))    # B3GAT1

CLI

robust-protein-gene "ki--67"

Data model

The SQLite database stores:

• canonical gene symbols
• aliases/synonyms
• normalized alias keys used for robust lookup

Optional Ensembl bootstrap

If you want to enrich synonyms from Ensembl:

pip install "robust-protein-gene[ensembl]"

Then use robust_protein_gene.ensembl_import.bootstrap_from_ensembl(...) in your own workflow.