A scalable cross-time Context Graph model for reconstructing tumor cell dynamic responses from single-cell perturbation transcriptomics.
Project description
scConGraph: a scalable cross-time Context Graph model
scConGraph is a scalable bi-layer graph model that efficiently integrates cross-time context information, enabling the comprehensive analysis of tumor cell dynamic responses from paired perturbed or time-seiries single-cell transcriptomics.
System requirements
scConGraph is now available for Linux, with a Windows version planned for recent release. scConGraph requires only a standard computer with enough RAM to perform in-memory computations.
Installation
CINEMA-OT requires python version 3.7+. Install directly from pip with:
pip install scConGraph
The LINE toolkit achieved in LINUX version should be downloaded and installed from https://github.com/tangjianpku/LINE.git before using scConGraph.
Tutorial
The vignette of scConGraph can be found in the project wiki.
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