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siibra-toolbox-neuroimaging - siibra toolbox for assignment of neuroimaging signals to brain regions

Project description


siibra neuroimaging toolbox

Copyright 2020-2021, Forschungszentrum Jülich GmbH

Authors: Big Data Analytics Group, Institute of Neuroscience and Medicine (INM-1), Forschungszentrum Jülich GmbH

This repository provides a toolbox for siibra <>__ which provides functionalities to assign (typically thresholded) whole brain activation maps, as obtained from functional neuroimaging, to brain regions. Given an input volume in the form of a NIfTI file, the toolbox will segregate the input signal into connectec components, and then analyze overlap and correlation of each component with regions defined in an atlas. Per default, the Julich-Brain probabilistic cytoarchitectonic maps [AmuntsEtAl2020]_ defined in MNI152 space are used, and the input volume is assumed in the same physical space. The functionality is strongly inspired by similar functionalities of the popular SPM anatomy toolbox <>__ [EickhoffEtAl2005]_.

In the current implementation, the toolbox provides a Python library as well as an extension to the siibra-cli <>__ commandline client. We release installation packages on pypi, so you typically can just run pip install siibra-toolbox-neuroimaging to install the Python package and commandline extension.

Note that siibra-toolbox-neuroimaging is still in early development. Get in touch with us to discuss, and feel free to post issues here on github.

A typical workflow will look like this::

from siibra_toolbox_neuroimaging import AnatomicalAssignment my_input_file = ".nii.gz" analysis = AnatomicalAssignment() assignments, component_mask = analysis.analyze(my_input_file) analysis.create_report(assignments, my_input_file, component_mask)

The main result is a table listing for each detected component significantly overlapping brain regions and their properties, returned as a pandas DataFrame (assignments in the above example). From this, the library can generate a nicely formatted pdf report which also adds structural connectivity profiles for the regions. The same report can also be produced using the commandline interface, by the simple call siibra assign nifti <filename>.nii.gz. Future versions will provide an interactive plugin to siibra-explorer <>__, the interactive web browser hosted at

This repository contains an example notebook, which you can run in your browser using mybinder <>__ by clicking the following link:

.. image:: :target:

The toolbox relies on the functionalities of siibra-python, documented at It includes a catalogue of well documented code examples that walk you through the different concepts and functionalities. As a new user, it is recommended to go through these examples - they are easy and will quickly provide you with the right code snippets that get you started.


.. [EickhoffEtAl2005] Eickhoff S, Stephan KE, Mohlberg H, Grefkes C, Fink GR, Amunts K, Zilles K: A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data. NeuroImage 25(4), 1325-1335, 2005 .. [AmuntsEtAl2020] Amunts K, Mohlberg H, Bludau S, Zilles K.: Julich-Brain: A 3D probabilistic atlas of the human brain’s cytoarchitecture. Science. 2020;369(6506):988-992. doi:10.1126/science.abb4588


This software code is funded from the European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 945539 (Human Brain Project SGA3).

.. acknowledgments-end

.. |License| image:: :target:

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